MYH6 and HSPB2

Data Source:
BioGRID (two hybrid)

		MYH6	HSPB2
Description		myosin heavy chain 6	heat shock protein family B (small) member 2
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament	Nucleus Cytoplasm Cytosol
	Molecular Function	Microfilament Motor Activity Calmodulin Binding ATP Binding ATPase Activity Myosin Phosphatase Activity Protein Kinase Binding Actin-dependent ATPase Activity Actin Filament Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity
	Biological Process	In Utero Embryonic Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Protein Dephosphorylation Muscle Contraction Striated Muscle Contraction Adult Heart Development Visceral Muscle Development Regulation Of Heart Contraction Regulation Of Blood Pressure Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Myofibril Assembly Regulation Of ATPase Activity Sarcomere Organization ATP Metabolic Process Cardiac Muscle Fiber Development Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Heart Growth	Response To Unfolded Protein Regulation Of Catalytic Activity
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Aortic coarctation ( 29590334) Atrial fibrillation ( 30061737) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) Heart rate ( 23583979) P wave duration ( 28794112) P wave terminal force ( 28794112) PR interval ( 30046033 32439900) Pulse pressure ( 28135244 27618447 27618448 30578418) Resting heart rate ( 29769521 23183192 27798624 28270201 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure ( 27618447)
Interacting Genes		6 interacting genes: CALCOCO1 CALCOCO2 ESR1 HSPB2 POLR2A TRIM63	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		4624	3316
HPRD ID		01171	03712
Ensembl ID		ENSG00000197616	ENSG00000170276
Uniprot IDs		P13533	A8KAH6 Q16082
PDB IDs			6F2R
Enriched GO Terms of Interacting Partners?
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