MYH6 and CALCOCO1

Data Source:
BioGRID (pull down)

		MYH6	CALCOCO1
Description		myosin heavy chain 6	calcium binding and coiled-coil domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament	Nucleus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Microfilament Motor Activity Calmodulin Binding ATP Binding ATPase Activity Myosin Phosphatase Activity Protein Kinase Binding Actin-dependent ATPase Activity Actin Filament Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Nuclear Receptor Coactivator Activity Sequence-specific DNA Binding Metal Ion Binding Armadillo Repeat Domain Binding
	Biological Process	In Utero Embryonic Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Protein Dephosphorylation Muscle Contraction Striated Muscle Contraction Adult Heart Development Visceral Muscle Development Regulation Of Heart Contraction Regulation Of Blood Pressure Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Myofibril Assembly Regulation Of ATPase Activity Sarcomere Organization ATP Metabolic Process Cardiac Muscle Fiber Development Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Heart Growth	Signal Transduction Positive Regulation Of Gene Expression Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Aortic coarctation ( 29590334) Atrial fibrillation ( 30061737) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) Heart rate ( 23583979) P wave duration ( 28794112) P wave terminal force ( 28794112) PR interval ( 30046033 32439900) Pulse pressure ( 28135244 27618447 27618448 30578418) Resting heart rate ( 29769521 23183192 27798624 28270201 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure ( 27618447)	Panic disorder ( 19165232) Toenail selenium levels ( 25343990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CALCOCO1 CALCOCO2 ESR1 HSPB2 POLR2A TRIM63	35 interacting genes: APP APTX ARNT BFSP2 CEP19 CREBBP CRYBA2 CTNNBL1 CWF19L2 CYTH3 DUSP13 ENKD1 EP300 FAM161A FOSL1 GABARAPL1 GABARAPL2 GRIK2 IPP ISOC1 KRT15 MAPK1 MYH6 NDC80 NEDD4 PCBD1 POLR2A PRKAA2 RNF8 SH3GL3 SMURF1 SRPK2 TBC1D15 TBC1D17 ZMAT2
Entrez ID		4624	57658
HPRD ID		01171	13868
Ensembl ID		ENSG00000197616	ENSG00000012822
Uniprot IDs		P13533	A0A024RAZ1 Q9P1Z2
PDB IDs
Enriched GO Terms of Interacting Partners?
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