Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
KMT2A and INS
Data Source:
BioGRID
(enzymatic study)
KMT2A
INS
Description
lysine methyltransferase 2A
insulin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL1 Complex
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Transport Vesicle
Endosome Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Secretory Granule Lumen
Molecular Function
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Identical Protein Binding
Protein Homodimerization Activity
Unmethylated CpG Binding
Lysine-acetylated Histone Binding
Protease Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Hormone Activity
Protein Binding
Identical Protein Binding
Biological Process
Apoptotic Process
Positive Regulation Of Transporter Activity
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Histone H4-K16 Acetylation
Histone H3-K4 Dimethylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Protein-containing Complex Assembly
Regulation Of Histone H3-K14 Acetylation
Histone H3-K4 Trimethylation
Histone H3-K4 Monomethylation
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of DNA Methylation
Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Cytokine Production
Negative Regulation Of Acute Inflammatory Response
Glucose Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Cellular Amino Acid Metabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Acute-phase Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Nitric Oxide Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Transmembrane Transporter Activity
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Localization
Negative Regulation Of NAD(P)H Oxidase Activity
Wound Healing
Negative Regulation Of Protein Catabolic Process
Glucose Homeostasis
Positive Regulation Of MAPK Cascade
Cellular Protein Metabolic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Glycogen Catabolic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Proteolysis
Negative Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Insulin Receptor Signaling Pathway
Alpha-beta T Cell Activation
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Secretion
Negative Regulation Of Protein Secretion
Cognition
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Respiratory Burst
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Dendritic Spine Maintenance
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Neuron Projection Maintenance
Negative Regulation Of Feeding Behavior
Pathways
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Regulation of gene expression in beta cells
Insulin processing
Insulin processing
Synthesis, secretion, and deacylation of Ghrelin
Regulation of insulin secretion
COPI-mediated anterograde transport
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Amyloid fiber formation
Drugs
Zinc
M-Cresol
Myristic acid
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Maturity onset diabetes of the young (MODY)
Type I diabetes mellitus
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolic syndrome (
31589552
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Birth weight (
27680694
)
Celiac disease (
23936387
)
Latent autoimmune diabetes vs. type 2 diabetes (
30254083
)
Pediatric autoimmune diseases (
26301688
)
Prostate cancer (
19767753
)
Prostate cancer (SNP x SNP interaction) (
22219177
)
Type 1 diabetes (
30659077
21829393
17632545
25751624
32005708
19430480
17554260
31152121
)
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) (
29310926
)
Type 1 diabetes in high risk HLA genotype individuals (time to event) (
29310926
)
Type 2 diabetes (
31324766
30297969
31049640
32499647
30718926
)
Interacting Genes
31 interacting genes:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
FASLG
H3-3A
H3-4
H3C1
H3C14
HCFC1
HCFC2
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
RBBP5
RNF2
SBF1
SET
SVIL
TAF9
TASP1
TOP1
WDR5
31 interacting genes:
ADAMTSL4
APP
CCN3
CPE
CRYAB
CTSB
CTSD
CTSE
CYSRT1
GCK
HLA-DQA2
HLA-DQB1
HSPA1A
HSPB1
IDE
IGF1R
IGFBP7
INSR
KMT2A
KRTAP1-1
KRTAP1-3
LRP2
MAPK6
NBPF19
NOTCH2NLA
PTEN
RB1
RGS20
SYTL4
TCF4
TXNDC17
Entrez ID
4297
3630
HPRD ID
01162
01455
Ensembl ID
ENSG00000118058
ENSG00000254647
Uniprot IDs
Q03164
I3WAC9
P01308
PDB IDs
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2MSR
2MTN
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
4NW3
5F5E
5F6L
5SVH
6EMQ
6KIU
6KIV
6KIX
6KIZ
6PWV
6PWW
6U9K
6U9M
6U9N
6U9R
1A7F
1AI0
1AIY
1B9E
1BEN
1EFE
1EV3
1EV6
1EVR
1FU2
1FUB
1G7A
1G7B
1GUJ
1HIQ
1HIS
1HIT
1HLS
1HTV
1HUI
1IOG
1IOH
1J73
1JCA
1JCO
1JK8
1K3M
1KMF
1LKQ
1LPH
1MHI
1MHJ
1MSO
1OS3
1OS4
1Q4V
1QIY
1QIZ
1QJ0
1RWE
1SF1
1SJT
1SJU
1T0C
1T1K
1T1P
1T1Q
1TRZ
1TYL
1TYM
1UZ9
1VKT
1W8P
1XDA
1XGL
1XW7
1ZEG
1ZEH
1ZNJ
2AIY
2C8Q
2C8R
2CEU
2G54
2G56
2H67
2HH4
2HHO
2HIU
2JMN
2JUM
2JUU
2JUV
2JV1
2JZQ
2K91
2K9R
2KJJ
2KJU
2KQP
2KQQ
2KXK
2L1Y
2L1Z
2LGB
2LWZ
2M1D
2M1E
2M2M
2M2N
2M2O
2M2P
2MLI
2MPG
2MPI
2MVC
2MVD
2N2V
2N2W
2N2X
2OLY
2OLZ
2OM0
2OM1
2OMG
2OMH
2OMI
2OMQ
2QIU
2R34
2R35
2R36
2RN5
2VJZ
2VK0
2W44
2WBY
2WC0
2WRU
2WRV
2WRW
2WRX
2WS0
2WS1
2WS4
2WS6
2WS7
3AIY
3BXQ
3E7Y
3E7Z
3EXX
3FQ9
3HYD
3I3Z
3I40
3ILG
3INC
3IR0
3JSD
3KQ6
3P2X
3P33
3Q6E
3ROV
3TT8
3U4N
3UTQ
3UTS
3UTT
3V19
3V1G
3W11
3W12
3W13
3W7Y
3W7Z
3W80
3ZI3
3ZQR
3ZS2
3ZU1
4AIY
4AJX
4AJZ
4AK0
4AKJ
4CXL
4CXN
4CY7
4EFX
4EWW
4EWX
4EWZ
4EX0
4EX1
4EXX
4EY1
4EY9
4EYD
4EYN
4EYP
4F0N
4F0O
4F1A
4F1B
4F1C
4F1D
4F1F
4F1G
4F4T
4F4V
4F51
4F8F
4FG3
4FKA
4GBC
4GBI
4GBK
4GBL
4GBN
4IUZ
4IYD
4IYF
4NIB
4OGA
4P65
4RXW
4UNE
4UNG
4UNH
4WDI
4XC4
4Y19
4Y1A
4Z76
4Z77
4Z78
5AIY
5BOQ
5BPO
5BQQ
5BTS
5C0D
5CJO
5CNY
5CO2
5CO6
5CO9
5E7W
5EMS
5EN9
5ENA
5HPR
5HPU
5HQI
5HRQ
5HYJ
5MAM
5MHD
5MT3
5MT9
5MWQ
5T7R
5UDP
5UOZ
5UQA
5URT
5URU
5USP
5USS
5USV
5UU2
5UU3
5UU4
5VIZ
5WBT
5WDM
5WOB
6B3Q
6B70
6BFC
6CE7
6CE9
6CEB
6CK2
6GNQ
6GV0
6H3M
6HN5
6JK8
6JR3
6K59
6NWV
6O17
6P4Z
6S34
6S4I
6S4J
6SOF
6TYH
6U46
6VEP
6VET
6X4X
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?