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KMT2A and WDR5
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
KMT2A
WDR5
Description
lysine methyltransferase 2A
WD repeat domain 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL1 Complex
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Histone Methyltransferase Complex
MLL3/4 Complex
Set1C/COMPASS Complex
MLL1 Complex
Molecular Function
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Identical Protein Binding
Protein Homodimerization Activity
Unmethylated CpG Binding
Lysine-acetylated Histone Binding
Protein Binding
Methylated Histone Binding
Histone Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Biological Process
Apoptotic Process
Positive Regulation Of Transporter Activity
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Histone H4-K16 Acetylation
Histone H3-K4 Dimethylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Protein-containing Complex Assembly
Regulation Of Histone H3-K14 Acetylation
Histone H3-K4 Trimethylation
Histone H3-K4 Monomethylation
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of DNA Methylation
Regulation Of Histone H3-K9 Acetylation
Skeletal System Development
Neuron Projection Development
Post-translational Protein Modification
Histone H3 Acetylation
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Pathways
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
PKMTs methylate histone lysines
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Neddylation
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolic syndrome (
31589552
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Cerebrospinal fluid t-tau levels in normal cognition (
29274321
)
Intraocular pressure (
30591961
)
Interacting Genes
31 interacting genes:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
FASLG
H3-3A
H3-4
H3C1
H3C14
HCFC1
HCFC2
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
RBBP5
RNF2
SBF1
SET
SVIL
TAF9
TASP1
TOP1
WDR5
37 interacting genes:
ANAPC2
APP
ASH2L
ATN1
BBC3
BHLHE41
CHD8
FAM199X
H1-2
H3-4
H3C1
H4-16
HSF2
IKBKG
KANSL1
KANSL2
KMT2A
MARF1
MBIP
MDM4
MEOX2
MLLT1
NR2E3
PDE9A
POU5F1
PRMT5
PRNP
RBBP5
RUSC1-AS1
SRPK2
SRRM4
SSX2IP
TERF2IP
TP53
WWP2
ZBTB48
ZXDC
Entrez ID
4297
11091
HPRD ID
01162
10614
Ensembl ID
ENSG00000118058
ENSG00000196363
Uniprot IDs
Q03164
P61964
PDB IDs
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2MSR
2MTN
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
4NW3
5F5E
5F6L
5SVH
6EMQ
6KIU
6KIV
6KIX
6KIZ
6PWV
6PWW
6U9K
6U9M
6U9N
6U9R
2CNX
2CO0
2G99
2G9A
2GNQ
2H13
2H14
2H68
2H6K
2H6N
2H6Q
2H9L
2H9M
2H9N
2H9P
2O9K
3EG6
3EMH
3MXX
3N0D
3N0E
3P4F
3PSL
3SMR
3UR4
3UVK
3UVL
3UVM
3UVN
3UVO
4A7J
4CY1
4CY2
4ERQ
4ERY
4ERZ
4ES0
4ESG
4EWR
4GM3
4GM8
4GM9
4GMB
4IA9
4O45
4QL1
4Y7R
5EAL
5EAM
5EAP
5EAR
5M23
5M25
5SXM
5VFC
6BYN
6D9X
6DAI
6DAK
6DAR
6DAS
6DY7
6DYA
6E1Y
6E1Z
6E22
6E23
6IAM
6KIU
6KIV
6KIW
6KIX
6KIZ
6OFZ
6OI0
6OI1
6OI2
6OI3
6PG3
6PG4
6PG5
6PG6
6PG7
6PG8
6PG9
6PGA
6PGB
6PGC
6PGD
6PGE
6PGF
6PWV
6PWW
6U5M
6U5Y
6U6W
6U80
6U8B
6U8L
6U8O
6UCS
6UFX
6UHY
6UHZ
6UIF
6UIK
6UJ4
6UJH
6UJJ
6UJL
6UOZ
Enriched GO Terms of Interacting Partners
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