INS and LRP2

Data Source:
HPRD (in vitro)

		INS	LRP2
Description		insulin	LDL receptor related protein 2
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Transport Vesicle Endosome Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Secretory Granule Lumen	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Brush Border Membrane Endosome Lumen Receptor Complex Extracellular Exosome
	Molecular Function	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Hormone Binding Chaperone Binding Protein Transporter Activity
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Transmembrane Transporter Activity Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Negative Regulation Of Protein Catabolic Process Glucose Homeostasis Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Synaptic Plasticity Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Cognition Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dendritic Spine Maintenance Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Negative Regulation Of Feeding Behavior	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Protein Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Positive Regulation Of Protein Kinase B Signaling Vagina Development Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways		Regulation of gene expression in beta cells Insulin processing Insulin processing Synthesis, secretion, and deacylation of Ghrelin Regulation of insulin secretion COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport
Drugs		Zinc M-Cresol Myristic acid Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Urokinase Insulin pork Gentamicin
Diseases		Maturity onset diabetes of the young (MODY) Type I diabetes mellitus Permanent neonatal diabetes mellitus (PNDM)	Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 19767753) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes ( 30659077 21829393 17632545 25751624 32005708 19430480 17554260 31152121) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 30297969 31049640 32499647 30718926)	Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29124443 29403010) Urate levels ( 31578528 20139978)
Interacting Genes		31 interacting genes: ADAMTSL4 APP CCN3 CPE CRYAB CTSB CTSD CTSE CYSRT1 GCK HLA-DQA2 HLA-DQB1 HSPA1A HSPB1 IDE IGF1R IGFBP7 INSR KMT2A KRTAP1-1 KRTAP1-3 LRP2 MAPK6 NBPF19 NOTCH2NLA PTEN RB1 RGS20 SYTL4 TCF4 TXNDC17	51 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		3630	4036
HPRD ID		01455	02509
Ensembl ID		ENSG00000254647	ENSG00000081479
Uniprot IDs		I3WAC9 P01308	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2MLI 2MPG 2MPI 2MVC 2MVD 2N2V 2N2W 2N2X 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2OMQ 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4CXL 4CXN 4CY7 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 4IYD 4IYF 4NIB 4OGA 4P65 4RXW 4UNE 4UNG 4UNH 4WDI 4XC4 4Y19 4Y1A 4Z76 4Z77 4Z78 5AIY 5BOQ 5BPO 5BQQ 5BTS 5C0D 5CJO 5CNY 5CO2 5CO6 5CO9 5E7W 5EMS 5EN9 5ENA 5HPR 5HPU 5HQI 5HRQ 5HYJ 5MAM 5MHD 5MT3 5MT9 5MWQ 5T7R 5UDP 5UOZ 5UQA 5URT 5URU 5USP 5USS 5USV 5UU2 5UU3 5UU4 5VIZ 5WBT 5WDM 5WOB 6B3Q 6B70 6BFC 6CE7 6CE9 6CEB 6CK2 6GNQ 6GV0 6H3M 6HN5 6JK8 6JR3 6K59 6NWV 6O17 6P4Z 6S34 6S4I 6S4J 6SOF 6TYH 6U46 6VEP 6VET 6X4X	2M0P
Enriched GO Terms of Interacting Partners?
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