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KMT2A and BMI1
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
KMT2A
BMI1
Description
lysine methyltransferase 2A
BMI1 proto-oncogene, polycomb ring finger
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL1 Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
PcG Protein Complex
PRC1 Complex
Molecular Function
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Identical Protein Binding
Protein Homodimerization Activity
Unmethylated CpG Binding
Lysine-acetylated Histone Binding
Protein Binding
Zinc Ion Binding
RING-like Zinc Finger Domain Binding
Promoter-specific Chromatin Binding
Biological Process
Apoptotic Process
Positive Regulation Of Transporter Activity
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Histone H4-K16 Acetylation
Histone H3-K4 Dimethylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Protein-containing Complex Assembly
Regulation Of Histone H3-K14 Acetylation
Histone H3-K4 Trimethylation
Histone H3-K4 Monomethylation
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of DNA Methylation
Regulation Of Histone H3-K9 Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Silencing
Segment Specification
Regulation Of Gene Expression
Hemopoiesis
Histone H2A-K119 Monoubiquitination
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of G0 To G1 Transition
Pathways
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Penile cancer
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolic syndrome (
31589552
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Prostate-specific antigen levels (
28139693
)
Interacting Genes
31 interacting genes:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
FASLG
H3-3A
H3-4
H3C1
H3C14
HCFC1
HCFC2
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
RBBP5
RNF2
SBF1
SET
SVIL
TAF9
TASP1
TOP1
WDR5
42 interacting genes:
CASC9
CBX8
CEP126
CSNK2B
E2F6
FOXS1
H2AC18
H2AC20
H2AC4
H2AX
H3-4
HSF2BP
IMMT
KAT5
KMT2A
LRIF1
MAPK14
MLLT1
MUC1
NDEL1
PCBP2-OT1
PCGF3
PCGF6
PGR
PHC1
PHC2
PTN
RING1
RNF114
RNF2
RRM1
SOCS2
TRIM27
TUSC3
UBE2D2
UBE2D3
UBE2I
USP11
USP15
VPS11
WHRN
ZBTB16
Entrez ID
4297
648
HPRD ID
01162
01277
Ensembl ID
ENSG00000118058
ENSG00000168283
Uniprot IDs
Q03164
P35226
PDB IDs
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2MSR
2MTN
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
4NW3
5F5E
5F6L
5SVH
6EMQ
6KIU
6KIV
6KIX
6KIZ
6PWV
6PWW
6U9K
6U9M
6U9N
6U9R
2H0D
2NA1
3RPG
4R8P
5FR6
Enriched GO Terms of Interacting Partners
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