INS and NBPF19

Data Source:
BioGRID (two hybrid)

		INS	NBPF19
Description		insulin	NBPF member 19
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Transport Vesicle Endosome Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Secretory Granule Lumen	Cytoplasm
	Molecular Function	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Transmembrane Transporter Activity Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Negative Regulation Of Protein Catabolic Process Glucose Homeostasis Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Synaptic Plasticity Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Cognition Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dendritic Spine Maintenance Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Negative Regulation Of Feeding Behavior
Pathways		Regulation of gene expression in beta cells Insulin processing Insulin processing Synthesis, secretion, and deacylation of Ghrelin Regulation of insulin secretion COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation
Drugs		Zinc M-Cresol Myristic acid Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Maturity onset diabetes of the young (MODY) Type I diabetes mellitus Permanent neonatal diabetes mellitus (PNDM)
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 19767753) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes ( 30659077 21829393 17632545 25751624 32005708 19430480 17554260 31152121) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 30297969 31049640 32499647 30718926)	Serum uric acid levels ( 30993211)
Interacting Genes		31 interacting genes: ADAMTSL4 APP CCN3 CPE CRYAB CTSB CTSD CTSE CYSRT1 GCK HLA-DQA2 HLA-DQB1 HSPA1A HSPB1 IDE IGF1R IGFBP7 INSR KMT2A KRTAP1-1 KRTAP1-3 LRP2 MAPK6 NBPF19 NOTCH2NLA PTEN RB1 RGS20 SYTL4 TCF4 TXNDC17	223 interacting genes: ADAM12 ADAMTSL4 AGXT ALDH16A1 ALPP ANKS1A AQP1 ATG9A ATP5F1D BCAM BMP7 BRME1 CARHSP1 CATSPER1 CCER1 CD164 CELF5 CERK CHCHD3 CHIC2 CHRD CHRNG CNNM3 COL8A1 CREB5 CRH CRY2 CST2 CST9L CTNNBIP1 CTSZ CXCL16 CYHR1 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGKQ DHRS1 DMRT3 DOCK2 DRD5 EMC7 F10 FADS2 FAM221A FAM71C FAM90A1 FBXW5 FRS3 FTHL17 FZD10 GLP1R GLYAT GNE GSTP1 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSPA12B ICAM4 IL10 INO80B INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 LRFN4 LYVE1 MACO1 MAPKBP1 MELTF MFSD13A MOS MRGBP MRPL40 MTA1 MXD3 MXI1 MYO15B MYPOP NECTIN2 NECTIN3 NEDD9 NMU NPDC1 NR1D2 NTM NTN4 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCSK5 PGAP6 PHLDA1 PIGS PLEKHN1 PRF1 PRR35 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAB3IL1 RAMP3 RASD1 RECK RNF111 RPS19BP1 RTN4RL1 SCNM1 SEMA3B SEMA4C SHFL SLC22A5 SLC23A1 SLC43A2 SLC5A5 SLC6A20 SMCP SPATA24 SPATA8 SPG7 SPPL2C SPRY1 STAC STK16 TAPBPL TCAF1 THAP7 TLE5 TMEFF2 TMEM150A TMIE TNIP3 TNS2 TRAPPC14 TRIM42 TROAP TSPAN4 TTPA UTP23 UXT VASN WDR25 ZDHHC1 ZNF124 ZNF319 ZNF330 ZNF408 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF786 ZNF837
Entrez ID		3630	101060226
HPRD ID		01455
Ensembl ID		ENSG00000254647	ENSG00000271383
Uniprot IDs		I3WAC9 P01308
PDB IDs		1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2MLI 2MPG 2MPI 2MVC 2MVD 2N2V 2N2W 2N2X 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2OMQ 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4CXL 4CXN 4CY7 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 4IYD 4IYF 4NIB 4OGA 4P65 4RXW 4UNE 4UNG 4UNH 4WDI 4XC4 4Y19 4Y1A 4Z76 4Z77 4Z78 5AIY 5BOQ 5BPO 5BQQ 5BTS 5C0D 5CJO 5CNY 5CO2 5CO6 5CO9 5E7W 5EMS 5EN9 5ENA 5HPR 5HPU 5HQI 5HRQ 5HYJ 5MAM 5MHD 5MT3 5MT9 5MWQ 5T7R 5UDP 5UOZ 5UQA 5URT 5URU 5USP 5USS 5USV 5UU2 5UU3 5UU4 5VIZ 5WBT 5WDM 5WOB 6B3Q 6B70 6BFC 6CE7 6CE9 6CEB 6CK2 6GNQ 6GV0 6H3M 6HN5 6JK8 6JR3 6K59 6NWV 6O17 6P4Z 6S34 6S4I 6S4J 6SOF 6TYH 6U46 6VEP 6VET 6X4X
Enriched GO Terms of Interacting Partners?
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