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KMT2A and PAF1
Data Source:
BioGRID
(genetic interference, affinity chromatography technology, affinity chromatography technology, pull down)
KMT2A
PAF1
Description
lysine methyltransferase 2A
PAF1 homolog, Paf1/RNA polymerase II complex component
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL1 Complex
Nucleoplasm
Cytoplasm
Membrane
Cdc73/Paf1 Complex
Cell Junction
Transcriptionally Active Chromatin
Molecular Function
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Identical Protein Binding
Protein Homodimerization Activity
Unmethylated CpG Binding
Lysine-acetylated Histone Binding
RNA Polymerase II Complex Binding
Chromatin Binding
Protein Binding
Biological Process
Apoptotic Process
Positive Regulation Of Transporter Activity
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Histone H4-K16 Acetylation
Histone H3-K4 Dimethylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Protein-containing Complex Assembly
Regulation Of Histone H3-K14 Acetylation
Histone H3-K4 Trimethylation
Histone H3-K4 Monomethylation
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of DNA Methylation
Regulation Of Histone H3-K9 Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
Endodermal Cell Fate Commitment
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
MRNA Polyadenylation
Histone Monoubiquitination
Wnt Signaling Pathway
Protein Ubiquitination
Nucleosome Positioning
Stem Cell Population Maintenance
Positive Regulation Of Histone Methylation
Positive Regulation Of MRNA 3'-end Processing
Histone H2B Ubiquitination
Protein Localization To Nucleus
Negative Regulation Of Myeloid Cell Differentiation
Cellular Response To Lipopolysaccharide
Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolic syndrome (
31589552
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Interacting Genes
31 interacting genes:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
FASLG
H3-3A
H3-4
H3C1
H3C14
HCFC1
HCFC2
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
RBBP5
RNF2
SBF1
SET
SVIL
TAF9
TASP1
TOP1
WDR5
17 interacting genes:
ENO1
ERCC6
FXR2
H1-2
H3C1
HSPB1
KAT8
KMT2A
LEO1
MLLT1
MSL1
MSL2
MSL3
RNF20
SUMO2
TCEA1
TULP3
Entrez ID
4297
54623
HPRD ID
01162
10140
Ensembl ID
ENSG00000118058
ENSG00000006712
Uniprot IDs
Q03164
A0A024R0H6
Q8N7H5
PDB IDs
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2MSR
2MTN
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
4NW3
5F5E
5F6L
5SVH
6EMQ
6KIU
6KIV
6KIX
6KIZ
6PWV
6PWW
6U9K
6U9M
6U9N
6U9R
4M6T
5ZYQ
6GMH
6TED
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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