MGST3 and APOD

Data Source:
BioGRID (two hybrid)

		MGST3	APOD
Description		microsomal glutathione S-transferase 3	apolipoprotein D
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Leukotriene Biosynthetic Process Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Response To Drug Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways		Glutathione conjugation Aflatoxin activation and detoxification	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		Glutathione	Vitamin A Copper
Diseases
GWAS		Metabolite levels ( 23823483) Total ventricular volume ( 21116278)	HDL cholesterol levels ( 32203549)
Interacting Genes		86 interacting genes: AGPAT4 AGTRAP APOD APOL2 AQP1 AQP10 AQP3 ARL6IP1 ARL6IP6 BET1 BMP10 C11orf24 C14orf180 C3orf52 CACNG1 CCNC CDIPT CLCA4 CLRN1 CMTM5 CREB3L1 CTSA CYBC1 ERG28 F10 FAXDC2 FUNDC2 FXYD6 GIMAP1 GIMAP5 GPR152 GPX8 GRM2 HMOX2 ITGAM LEMD1 LMNA LPAR3 LRP10 MIP MRM1 MTIF3 NEU1 NINJ2 NKG7 NRM NSG1 PAGE1 PLN PLP1 PLP2 PLPP4 SCD SCN3B SEC22B SLC1A3 SLC2A5 SLC35A1 SLC39A9 SLC7A1 SMCO4 SNAP47 SNORC STX3 STX7 STX8 SYS1 TFAM TFRC TMEM107 TMEM109 TMEM120B TMEM140 TMEM229B TMEM60 TMEM86B TMX2 TSPAN12 TSPAN2 TSPAN33 UBIAD1 UNC50 VAMP3 VAMP4 YIF1A ZFPL1	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		4259	347
HPRD ID		05192	00134
Ensembl ID		ENSG00000143198	ENSG00000189058
Uniprot IDs		A0A024R8Z1 O14880	P05090
PDB IDs			2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?
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