MGST3 and AQP3

Data Source:
BioGRID (two hybrid)

		MGST3	AQP3
Description		microsomal glutathione S-transferase 3	aquaporin 3 (Gill blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Identical Protein Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Leukotriene Biosynthetic Process Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process	Positive Regulation Of Immune System Process Renal Water Homeostasis Water Transport Glycerol Transport Response To Retinoic Acid Response To Vitamin D Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Renal Water Absorption Cellular Response To Hypoxia Urea Transmembrane Transport Cellular Response To Oxygen-glucose Deprivation
Pathways		Glutathione conjugation Aflatoxin activation and detoxification	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Glutathione	Sennosides
Diseases
GWAS		Metabolite levels ( 23823483) Total ventricular volume ( 21116278)	Lung adenocarcinoma ( 28604730 31326317) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		86 interacting genes: AGPAT4 AGTRAP APOD APOL2 AQP1 AQP10 AQP3 ARL6IP1 ARL6IP6 BET1 BMP10 C11orf24 C14orf180 C3orf52 CACNG1 CCNC CDIPT CLCA4 CLRN1 CMTM5 CREB3L1 CTSA CYBC1 ERG28 F10 FAXDC2 FUNDC2 FXYD6 GIMAP1 GIMAP5 GPR152 GPX8 GRM2 HMOX2 ITGAM LEMD1 LMNA LPAR3 LRP10 MIP MRM1 MTIF3 NEU1 NINJ2 NKG7 NRM NSG1 PAGE1 PLN PLP1 PLP2 PLPP4 SCD SCN3B SEC22B SLC1A3 SLC2A5 SLC35A1 SLC39A9 SLC7A1 SMCO4 SNAP47 SNORC STX3 STX7 STX8 SYS1 TFAM TFRC TMEM107 TMEM109 TMEM120B TMEM140 TMEM229B TMEM60 TMEM86B TMX2 TSPAN12 TSPAN2 TSPAN33 UBIAD1 UNC50 VAMP3 VAMP4 YIF1A ZFPL1	28 interacting genes: C14orf180 CD79A ERG28 ERGIC3 EVI2B FAM209A GIMAP5 GPR152 GPX8 HIBADH LEUTX LMNA MFF MGST3 MRM1 MUC1 OLFM4 PLD2 PLP2 SAR1A SGPL1 SSMEM1 STX1A TMEM107 TMEM42 TMEM86A TNF VASN
Entrez ID		4259	360
HPRD ID		05192	08970
Ensembl ID		ENSG00000143198	ENSG00000165272
Uniprot IDs		A0A024R8Z1 O14880	A0A2R8Y2R4 Q92482
PDB IDs
Enriched GO Terms of Interacting Partners?
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