EPCAM and CLDN7

Data Source:
HPRD (in vitro)

		EPCAM	CLDN7
Description		epithelial cell adhesion molecule	claudin 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane
	Molecular Function	Protein Binding Protein-containing Complex Binding Cadherin Binding Involved In Cell-cell Adhesion	Structural Molecule Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Leukocyte Migration Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Stem Cell Proliferation	Cell Adhesion Negative Regulation Of Cell Adhesion Positive Regulation Of Cell Population Proliferation Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Process Response To Ethanol Bicellular Tight Junction Assembly Positive Regulation Of Cell Motility
Pathways		Cell surface interactions at the vascular wall	Tight junction interactions
Drugs		Oportuzumab monatox ING-1 Catumaxomab Technetium Tc-99m nofetumomab merpentan Hypromellose
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		epithelial cell adhesion molecule levels ( 25147954)	Birth weight ( 31043758 27680694) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758)
Interacting Genes		2 interacting genes: CLDN7 TSC22D2	77 interacting genes: AIG1 ANKRD46 APOD AQP2 ASGR1 BCL2L2 BET1 BMP10 C3orf52 CD53 CD72 CLN6 CMTM5 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB561D2 CYB5B CYBC1 EDDM3B EMP3 EPCAM ERG28 ERMP1 FAXDC2 FXYD6 GIMAP5 GLP1R GPR37L1 HGD IGFBP5 ITM2A JAGN1 LAT LEPROTL1 LPAR3 LSMEM2 MAL MALL MFSD5 MS4A13 NDUFB11 NIPAL4 NKG7 OLFM4 PGAP2 PLN RHOXF2 RPRM RTP2 SCAMP4 SCARF1 SEC22B SERTM1 SLC38A7 SYNE4 TJP1 TMEM100 TMEM11 TMEM128 TMEM140 TMEM147 TMEM44 TMEM60 TMEM97 TNF TRARG1 TSPAN33 UBIAD1 UNC93B1 UPK1B UPK2 VAMP3 VAMP5 VSTM1
Entrez ID		4072	1366
HPRD ID		01709	07633
Ensembl ID		ENSG00000119888	ENSG00000181885
Uniprot IDs		P16422	A0A384ME58 F5H496 O95471
PDB IDs		4MZV 6I07
Enriched GO Terms of Interacting Partners?
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