CENPP and RNF126

Data Source:
BioGRID (two hybrid)

		CENPP	RNF126
Description		centromere protein P	ring finger protein 126
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	CENP-A Containing Nucleosome Assembly	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) End-stage renal disease ( 29885931) HDL cholesterol levels ( 32203549) Height ( 28552196 31562340) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		27 interacting genes: ATP6V0D2 BACH2 C2orf88 CCDC33 CCDC85B CENPO CEP44 GOLGA2 HAUS1 KIAA1328 KLC3 LMNA MBD3 NHLH1 NTAQ1 PKNOX2 POLR3K RNF126 RPIA SERTAD3 STXBP1 SYCE1L TEX11 TOX2 USHBP1 ZNF341 ZNF765	39 interacting genes: AICDA BAG6 CDKN1A CENPP CSNK2B E2F1 EGFR FXN HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		401541	55658
HPRD ID		17989	11501
Ensembl ID		ENSG00000188312	ENSG00000070423
Uniprot IDs		Q6IPU0 Q7Z672	A0A024R206 A8K0Q1 Q9BV68
PDB IDs			2N9O 2N9P
Enriched GO Terms of Interacting Partners?
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