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LIG4 and GAPDH
Data Source:
BioGRID
(two hybrid)
LIG4
GAPDH
Description
DNA ligase 4
glyceraldehyde-3-phosphate dehydrogenase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Cytoplasmic Ribonucleoprotein Granule
Nonhomologous End Joining Complex
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Nuclear Membrane
Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
GAIT Complex
Ribonucleoprotein Complex
Molecular Function
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity
Protein Binding
Microtubule Binding
Aspartic-type Endopeptidase Inhibitor Activity
Peptidyl-cysteine S-nitrosylase Activity
Identical Protein Binding
NADP Binding
NAD Binding
Disordered Domain Specific Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Gamma Radiation
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Chromosome Organization
Microtubule Cytoskeleton Organization
Positive Regulation Of Cytokine Production
Gluconeogenesis
Glycolytic Process
Negative Regulation Of Endopeptidase Activity
Regulation Of Macroautophagy
Negative Regulation Of Translation
Killing Of Cells Of Other Organism
Peptidyl-cysteine S-trans-nitrosylation
Protein Stabilization
Defense Response To Fungus
Neuron Apoptotic Process
Killing By Host Of Symbiont Cells
Canonical Glycolysis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Interferon-gamma
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Glycolysis
Gluconeogenesis
Drugs
NADH
Adenosine-5-Diphosphoribose
Thionicotinamide-Adenine-Dinucleotide
4-(2-Aminoethyl)Benzenesulfonyl Fluoride
Xanthinol
Copper
Artenimol
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Blood protein levels (
30072576
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
84 interacting genes:
ACD
ACTB
ACTC1
ANXA1
ANXA7
APP
AR
ARL15
ATN1
ATXN1
BID
BPGM
BTBD2
CAMK1
CAMK2B
CAMK4
CDKN1A
CDKN2A
CHP1
DUX4
DYNLL1
EGFR
ERBB2
FBXO7
FKBP6
GADD45A
GAS7
GOT2
GRIA2
GRM1
HES1
HNF4G
HSPB2
HTT
ITGB5
KARS1
KAT5
KCNE3
LAMA4
LAMTOR5
LIG4
LINC01554
MAPK1
MTNR1A
MYOC
NFYC
NR1H4
OSMR
OSTF1
PAFAH1B3
PCDHA4
PCNA
PDIA2
PGK1
PLD2
POT1
POU2F2
PPM1E
PRDX1
PRKCI
PRPF40A
PSEN1
PSMD11
PTPRF
RAB2A
RBM5
RPA2
RXFP4
S100A6
SERPINB9
SIAH1
SIRT1
SLC2A1
SLC2A4
SMN1
SNCA
SUMO4
TERF1
TINF2
TK1
TPPP
USP25
YWHAE
YWHAQ
Entrez ID
3981
2597
HPRD ID
03500
00713
Ensembl ID
ENSG00000174405
ENSG00000111640
Uniprot IDs
A0A024RE06
A0A0C4DGV9
A8K8Q4
P49917
P04406
V9HVZ4
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
1U8F
1ZNQ
2FEH
3GPD
4WNC
4WNI
6ADE
6IQ6
6YND
6YNE
6YNF
6YNH
Enriched GO Terms of Interacting Partners
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