LIG4 and EIF2AK1

Data Source:
BioGRID (two hybrid)

		LIG4	EIF2AK1
Description		DNA ligase 4	eukaryotic translation initiation factor 2 alpha kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Cytoplasmic Ribonucleoprotein Granule Nonhomologous End Joining Complex	Cytoplasm
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	Protein Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Gamma Radiation T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Chromosome Organization	Acute Inflammatory Response Phagocytosis Negative Regulation Of Cell Population Proliferation Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of EIF2 Alpha Phosphorylation By Heme Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process Iron Ion Homeostasis Integrated Stress Response Signaling HRI-mediated Signaling Response To Iron Ion Starvation
Pathways		2-LTR circle formation Nonhomologous End-Joining (NHEJ)	Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Fostamatinib
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	4 interacting genes: CDC37 EIF2S1 HSP90AA1 LIG4
Entrez ID		3981	27102
HPRD ID		03500	10684
Ensembl ID		ENSG00000174405	ENSG00000086232
Uniprot IDs		A0A024RE06 A0A0C4DGV9 A8K8Q4 P49917	A0A024QZU1 Q9BQI3
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG
Enriched GO Terms of Interacting Partners?
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