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LIG4 and MCRS1
Data Source:
BioGRID
(two hybrid)
LIG4
MCRS1
Description
DNA ligase 4
microspherule protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Cytoplasmic Ribonucleoprotein Granule
Nonhomologous End Joining Complex
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Polysome
Dendrite
Ino80 Complex
Perikaryon
NSL Complex
MLL1 Complex
Molecular Function
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
G-quadruplex RNA Binding
Protein Binding
Poly(U) RNA Binding
Poly(G) Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Gamma Radiation
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Chromosome Organization
DNA Repair
DNA Recombination
Cellular Protein Modification Process
Viral Process
Protein Deubiquitination
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleolus
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
HATs acetylate histones
UCH proteinases
DNA Damage Recognition in GG-NER
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
126 interacting genes:
AGGF1
AXIN2
BACH2
BEND3
BHLHA9
BHLHE40
BLM
BRD8
BRMS1
BRMS1L
C18orf25
C2CD6
C7orf57
C8orf34
CARD9
CAVIN2
CBY2
CCDC13
CCDC136
CCDC85B
CCHCR1
CCNH
CDCA7L
CEP44
CEP70
CNTROB
COIL
CREB3L3
CSRNP1
CYSRT1
CYTIP
DAXX
DRAP1
DVL2
EGR2
ERF
EVI5
FAM9A
FNDC8
FSD2
FXR1
FXR2
GAS7
GCC1
GEM
GIGYF1
GOLGA2
GPBP1
HMBOX1
HOOK2
IKZF1
IKZF3
IKZF4
INO80E
INSYN1
JAKMIP1
KANK2
KAT7
KDM1A
KIAA1958
KRT35
KRTAP10-7
KRTAP2-3
KRTAP2-4
KXD1
LIG4
LSM6
LZTS1
MAGEA11
MAGEA6
MAPK9
MED4
MEOX1
MFAP1
MIER2
MIER3
NAA10
NAB2
NKAPD1
NOP2
OSBPL3
PBK
PBX2
PCM1
PHC2
PIBF1
PINX1
PKNOX2
PPP1R13B
PRMT5
PSTPIP1
PTEN
RABEP1
RALYL
RARA
RETREG3
RIPPLY3
SH2B2
SNAPC5
SP4
SRRM4
SSMEM1
SUV39H1
TADA2B
TBC1D1
TERT
TFAP4
TLE5
TNIP1
TNNI1
TP63
TRIM37
TRIM41
TSPYL2
UPF3B
USHBP1
WASHC3
WBP11
XIAP
ZBTB22
ZCCHC10
ZCCHC12
ZNF23
ZNF639
ZNF8
ZRANB1
Entrez ID
3981
10445
HPRD ID
03500
11298
Ensembl ID
ENSG00000174405
ENSG00000187778
Uniprot IDs
A0A024RE06
A0A0C4DGV9
A8K8Q4
P49917
A0A024R134
Q96EZ8
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
Enriched GO Terms of Interacting Partners
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