LCAT and EXOSC10

Data Source:
BioGRID (two hybrid)

		LCAT	EXOSC10
Description		lecithin-cholesterol acyltransferase	exosome component 10
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine-sterol O-acyltransferase Activity Triglyceride Lipase Activity Protein Binding Apolipoprotein A-I Binding Platelet-activating Factor Acetyltransferase Activity	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		HDL remodeling	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease
GWAS		HDL cholesterol ( 24097068 24507774 18193043 20864672 19060906 19060910 21347282 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 31217584) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Total cholesterol levels ( 30275531) Total cholesterol levels in HDL ( 29084231)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		4 interacting genes: A2M APOA1 APOE EXOSC10	37 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		3931	5394
HPRD ID		06098	16180
Ensembl ID		ENSG00000213398	ENSG00000171824
Uniprot IDs		A0A140VK24 P04180	Q01780
PDB IDs		4X96 4XWG 4XX1 5BV7 5TXF 6MVD	2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R
Enriched GO Terms of Interacting Partners?
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