LCAT

Description		lecithin-cholesterol acyltransferase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine-sterol O-acyltransferase Activity Triglyceride Lipase Activity Protein Binding Apolipoprotein A-I Binding Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly
Pathways		HDL remodeling
Drugs
Diseases		Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease
GWAS		HDL cholesterol ( 24097068 24507774 18193043 20864672 19060906 19060910 21347282 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 31217584) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Total cholesterol levels ( 30275531) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		4 interacting genes: A2M APOA1 APOE EXOSC10
Entrez ID		3931
HPRD ID		06098
Ensembl ID		ENSG00000213398
Uniprot IDs		A0A140VK24 P04180
PDB IDs		4X96 4XWG 4XX1 5BV7 5TXF 6MVD
Enriched GO Terms of Interacting Partners?
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