GRXCR1 and ALAS1

Data Source:
BioGRID (two hybrid)

		GRXCR1	ALAS1
Description		glutaredoxin and cysteine rich domain containing 1	5'-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microvillus Stereocilium Kinocilium	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Molecular_function Protein Binding Protein Disulfide Oxidoreductase Activity	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Sensory Perception Of Sound Negative Regulation Of Phosphatase Activity Vestibular Receptor Cell Development Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Interferon alpha levels in systemic lupus erythematosus ( 25338677) Obesity-related traits ( 23251661) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Takayasu arteritis ( 25604533) Type 2 diabetes (age of onset) ( 28060188)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		9 interacting genes: ALAS1 BAIAP2L2 CAP2 INCA1 PICK1 PRDM6 SDCBP SNX32 TEX11	54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		389207	211
HPRD ID		19018	00505
Ensembl ID		ENSG00000215203	ENSG00000023330
Uniprot IDs		A8MXD5	B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?
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