KRT35 and TBC1D21

Data Source:
BioGRID (two hybrid)

		KRT35	TBC1D21
Description		keratin 35	TBC1 domain family member 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome	Acrosomal Vesicle Cytoskeleton Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding	Actin Binding GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Anatomical Structure Morphogenesis Keratinization Cornification	Intracellular Protein Transport Spermatogenesis Cell Differentiation Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS			Coffee consumption (cups per day) ( 31837886) Estimated glomerular filtration rate ( 31152163) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Feeling fed-up ( 29500382) Glucose homeostasis traits ( 25524916)
Interacting Genes		87 interacting genes: ABI3 ATG9A BCAS2 C1orf109 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446	29 interacting genes: APP CCDC158 CFAP53 EVI5L GAS2 GFAP GTF2E1 KIF26A KRT15 KRT35 KRT37 KRT38 KRT40 LCN2 MEOX2 NR1D2 NUTM1 PDCD2 PMF1 PMF1-BGLAP RAB3IP REL RIBC1 SAMD4A SEPTIN2 SNX7 STMN3 TCF12 TIMM10
Entrez ID		3886	161514
HPRD ID		04138	15473
Ensembl ID		ENSG00000197079	ENSG00000167139
Uniprot IDs		Q92764	Q8IYX1
PDB IDs
Enriched GO Terms of Interacting Partners?
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