TBC1D21 and PMF1

Data Source:
BioGRID (two hybrid)

		TBC1D21	PMF1
Description		TBC1 domain family member 21	polyamine modulated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoskeleton Extracellular Exosome	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleoplasm Transcription Regulator Complex Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding GTPase Activator Activity Protein Binding Small GTPase Binding	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding
	Biological Process	Intracellular Protein Transport Spermatogenesis Cell Differentiation Activation Of GTPase Activity Regulation Of Cilium Assembly	Transcription By RNA Polymerase II Cell Cycle Chromosome Segregation Positive Regulation Of Transcription, DNA-templated Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Estimated glomerular filtration rate ( 31152163) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Feeling fed-up ( 29500382) Glucose homeostasis traits ( 25524916)	Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Stroke ( 29531354) White matter hyperintensity burden ( 25663218)
Interacting Genes		29 interacting genes: APP CCDC158 CFAP53 EVI5L GAS2 GFAP GTF2E1 KIF26A KRT15 KRT35 KRT37 KRT38 KRT40 LCN2 MEOX2 NR1D2 NUTM1 PDCD2 PMF1 PMF1-BGLAP RAB3IP REL RIBC1 SAMD4A SEPTIN2 SNX7 STMN3 TCF12 TIMM10	24 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L TSNAX USHBP1
Entrez ID		161514	11243
HPRD ID		15473	11441
Ensembl ID		ENSG00000167139	ENSG00000160783
Uniprot IDs		Q8IYX1	Q6P1K2
PDB IDs			5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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