KRT35 and HDAC4

Data Source:
BioGRID (two hybrid)

		KRT35	HDAC4
Description		keratin 35	histone deacetylase 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Transcription Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin
	Molecular Function	Structural Molecule Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Anatomical Structure Morphogenesis Keratinization Cornification	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Development Chromatin Remodeling Protein Deacetylation Inflammatory Response Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Smooth Muscle Cell Migration Histone Deacetylation Protein Sumoylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of DNA-binding Transcription Factor Activity Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Male Mating Behavior Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Keratinization Formation of the cornified envelope	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF
Drugs			Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Body size at age 10 ( 32376654) Chronotype ( 30696823) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Diastolic blood pressure ( 30224653 30487518) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Heel bone mineral density ( 30598549) Intra-individual response time variability (selective attention) ( 30287865) Male-pattern baldness ( 22693459) Mean arterial pressure ( 29403010 30487518) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30487518)
Interacting Genes		87 interacting genes: ABI3 ATG9A BCAS2 C1orf109 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446	123 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ASB15 ATF3 ATRX BCL6 BCOR BEGAIN BICD2 BLZF1 BORCS8-MEF2B BRMS1 CACNA1C CADPS CALCOCO2 CAMK4 CBX5 CCDC125 CCDC136 CCNDBP1 CDKN1A CDPF1 CDR2 CDR2L CEBPD CEP70 CIITA CSRP3 CTBP1 DYDC1 EFEMP2 EFHC2 ESR1 FCHSD2 FSD2 GATA1 GCM1 GOLGA2 GOLGA6L9 GRIPAP1 GSK3B HAP1 HDAC3 HDAC7 HDAC9 HNF4A HOOK2 HSF2BP IFRD1 IKZF2 INCA1 JDP2 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MID2 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBID NFKBIE NPPB NR1H2 NR2C1 NR2C2 PICK1 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SSX2IP SUMO1 SUMO2 SYK TFIP11 TLE5 TNFRSF14 TRIB3 TRIM27 TSGA10 UBE2I VPS52 YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZMYND12 ZNF354A
Entrez ID		3886	9759
HPRD ID		04138	05610
Ensembl ID		ENSG00000197079	ENSG00000068024
Uniprot IDs		Q92764	P56524
PDB IDs			2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ
Enriched GO Terms of Interacting Partners?
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