POU4F2 and VWC2

Data Source:
BioGRID (two hybrid)

		POU4F2	VWC2
Description		POU class 4 homeobox 2	von Willebrand factor C domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck	Basement Membrane Interstitial Matrix Extracellular Space AMPA Glutamate Receptor Complex Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding Protein Binding Promoter-specific Chromatin Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of Transcription By RNA Polymerase II Spermatogenesis Axon Guidance Heart Development Sensory Perception Of Sound Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neuron Differentiation Intracellular Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding	Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation
Pathways		Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Malaria ( 31844061) Metabolite levels ( 23823483)	Blood protein levels ( 30072576 29875488) Body mass index ( 28892062 25673413) Lung cancer in never smokers ( 28604730) Neurological blood protein biomarker levels ( 31320639) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		75 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2	57 interacting genes: ABHD15 ADAMTSL4 ATPAF2 CAMLG CATSPER1 CNNM3 CRY2 CYSRT1 ENKD1 FAM90A1 FBXW5 FUCA2 GET3 GNE HAPLN2 HOXA1 HPCA HPCAL1 KANK2 KPRP KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 LCE1A LCE1C LCE1F LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A NTM OTX1 PFKFB1 POU4F2 PRPF31 SCNM1 SGTB SHFL SPRY1 TRAPPC14 UBQLN1 UBQLN2 VASN YY1 ZNF319 ZNF417 ZNF490 ZNF497 ZNF587 ZNF696 ZNF774 ZNF837
Entrez ID		5458	375567
HPRD ID		00220	18271
Ensembl ID		ENSG00000151615	ENSG00000188730
Uniprot IDs		Q12837	Q2TAL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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