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ITGB3 and PXN
Data Source:
BioGRID
(pull down)
ITGB3
PXN
Description
integrin subunit beta 3
paxillin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
Cell Surface
Platelet Alpha Granule Membrane
Lamellipodium Membrane
Filopodium Membrane
Microvillus Membrane
Ruffle Membrane
Protein-containing Complex
Integrin Alphav-beta3 Complex
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Alphav-beta3 Integrin-HMGB1 Complex
Melanosome
Receptor Complex
Synapse
Postsynaptic Membrane
Extracellular Exosome
Alphav-beta3 Integrin-vitronectin Complex
Glutamatergic Synapse
Stress Fiber
Cytosol
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Molecular Function
Virus Receptor Activity
Fibronectin Binding
Protease Binding
Protein Disulfide Isomerase Activity
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Coreceptor Activity
Fibroblast Growth Factor Binding
Enzyme Binding
C-X3-C Chemokine Binding
Insulin-like Growth Factor I Binding
Neuregulin Binding
Identical Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Cell Adhesion Molecule Binding
Extracellular Matrix Binding
Fibrinogen Binding
Transcription Coregulator Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Platelet Degranulation
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Blood Coagulation
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Smooth Muscle Cell Migration
Cell Migration
Protein Phosphopantetheinylation
Platelet Activation
Extracellular Matrix Organization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Activation Of Protein Kinase Activity
Negative Regulation Of Lipid Transport
Regulation Of Protein Localization
Cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Tube Development
Apolipoprotein A-I-mediated Signaling Pathway
Wound Healing
Apoptotic Cell Clearance
Regulation Of Bone Resorption
Viral Entry Into Host Cell
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mesodermal Cell Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Lipoprotein Metabolic Process
Leukocyte Migration
Negative Chemotaxis
Regulation Of Serotonin Uptake
Angiogenesis Involved In Wound Healing
Platelet Aggregation
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Regulation Of Transcription, DNA-templated
Muscle Contraction
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
Pathways
Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Syndecan interactions
Syndecan interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
Signal transduction by L1
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Abciximab
Eptifibatide
Antithymocyte immunoglobulin (rabbit)
Levothyroxine
Tirofiban
Resveratrol
Lefradafiban
LM-609
Fradafiban
Ferric maltol
Diseases
Glanzmann thrombasthenia
Allograft rejection
GWAS
Body mass index (
25673413
)
Brain morphology (MOSTest) (
32665545
)
Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure (
31586183
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
High chromosomal aberration frequency (chromosome type) (
31586183
)
Mean platelet volume (
27863252
)
Medication use (thyroid preparations) (
31015401
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Bipolar disorder (
31043756
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Interacting Genes
49 interacting genes:
AKT1
ANGPTL3
APP
CAPN1
CD36
CDK1
COL1A2
DAB1
DAB2
DOK1
EPS8
FBLN2
FGA
FGFR1
FGG
FLNA
FLNB
FN1
GRIA2
HRAS
ILK
ITGA2B
ITGA5
ITGAV
ITGB3BP
KDR
MAPK3
NID1
NUMB
P2RY2
P4HB
PDGFRA
PDGFRB
PDK1
PDPK1
PECAM1
PLA2G2A
PLA2G4A
PTK2
PTK2B
PXN
SHC1
SRC
TGM2
THBS1
THY1
TLN1
TNS2
VTN
87 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
PLEKHN1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
YES1
Entrez ID
3690
5829
HPRD ID
01428
03937
Ensembl ID
ENSG00000259207
ENSG00000089159
Uniprot IDs
P05106
A0A140VJQ8
P49023
PDB IDs
1JV2
1KUP
1KUZ
1L5G
1M1X
1M8O
1MIZ
1MK7
1MK9
1RN0
1S4X
1TYE
1U8C
2INI
2K9J
2KNC
2KV9
2L1C
2L91
2LJD
2LJE
2LJF
2MTP
2N9Y
2Q6W
2RMZ
2RN0
2VC2
2VDK
2VDL
2VDM
2VDN
2VDO
2VDP
2VDQ
2VDR
3FCS
3FCU
3IJE
3NID
3NIF
3NIG
3T3M
3T3P
3ZDX
3ZDY
3ZDZ
3ZE0
3ZE1
3ZE2
4CAK
4G1E
4G1M
4MMX
4MMY
4MMZ
4O02
4Z7N
4Z7O
4Z7Q
5HDB
6AVQ
6AVR
6AVU
6BXB
6BXF
6BXJ
6CKB
6MK0
6MSL
6MSU
6NAJ
6V4P
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
Enriched GO Terms of Interacting Partners
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