AQP2 and ELL2

Data Source:
BioGRID (two hybrid)

		AQP2	ELL2
Description		aquaporin 2	elongation factor for RNA polymerase II 2
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Nucleoplasm Transcription Elongation Factor Complex
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Albumin-globulin ratio ( 29403010) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) IgA levels ( 28628107) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Mean corpuscular hemoglobin ( 32888494) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 29403010) Serum total protein level ( 23022100) Telomere length ( 30185882)
Interacting Genes		60 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6	7 interacting genes: AFF4 AQP2 CASK EAF1 EXOC8 PRKAB2 SIAH1
Entrez ID		359	22936
HPRD ID		00141	11798
Ensembl ID		ENSG00000167580	ENSG00000118985
Uniprot IDs		P41181	O00472 Q59FW6 Q7Z656
PDB IDs		4NEF 4OJ2 6QF5	2E5N 5JW9
Enriched GO Terms of Interacting Partners?
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