ELL2 and EXOC8

Data Source:
BioGRID (two hybrid)

		ELL2	EXOC8
Description		elongation factor for RNA polymerase II 2	exocyst complex component 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Elongation Factor Complex	Exocyst Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Leading Edge Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II	Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Cellular Protein Localization
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) IgA levels ( 28628107) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Mean corpuscular hemoglobin ( 32888494) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 29403010) Serum total protein level ( 23022100) Telomere length ( 30185882)	Hemoglobin concentration ( 27863252)
Interacting Genes		7 interacting genes: AFF4 AQP2 CASK EAF1 EXOC8 PRKAB2 SIAH1	88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4
Entrez ID		22936	149371
HPRD ID		11798	09943
Ensembl ID		ENSG00000118985	ENSG00000116903
Uniprot IDs		O00472 Q59FW6 Q7Z656	Q8IYI6
PDB IDs		2E5N 5JW9
Enriched GO Terms of Interacting Partners?
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