ELL2 and AQP2

Data Source:
BioGRID (two hybrid)

		ELL2	AQP2
Description		elongation factor for RNA polymerase II 2	aquaporin 2
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GO Annotations	Cellular Component	Nucleoplasm Transcription Elongation Factor Complex	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Protein Binding	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Albumin-globulin ratio ( 29403010) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) IgA levels ( 28628107) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Mean corpuscular hemoglobin ( 32888494) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 29403010) Serum total protein level ( 23022100) Telomere length ( 30185882)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		7 interacting genes: AFF4 AQP2 CASK EAF1 EXOC8 PRKAB2 SIAH1	60 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		22936	359
HPRD ID		11798	00141
Ensembl ID		ENSG00000118985	ENSG00000167580
Uniprot IDs		O00472 Q59FW6 Q7Z656	P41181
PDB IDs		2E5N 5JW9	4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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