IDS and HTR6

Data Source:
BioGRID (two hybrid)

		IDS	HTR6
Description		iduronate 2-sulfatase	5-hydroxytryptamine receptor 6
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Lumen	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	Iduronate-2-sulfatase Activity Calcium Ion Binding Sulfuric Ester Hydrolase Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Glycosaminoglycan Catabolic Process Chondroitin Sulfate Catabolic Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases		Mucopolysaccharidosis type II (MPS2); Hunter syndrome
GWAS		Cognitive performance ( 20125193) Idiopathic downbeat nystagmus ( 32157568)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		1 interacting genes: HTR6	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		3423	3362
HPRD ID		02402	03066
Ensembl ID		ENSG00000010404	ENSG00000158748
Uniprot IDs		B4DGD7 P22304	P50406
PDB IDs		5FQL 6IOZ
Enriched GO Terms of Interacting Partners?
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