KLHL38 and LHX3

Data Source:
BioGRID (two hybrid)

		KLHL38	LHX3
Description		kelch like family member 38	LIM homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding
	Biological Process		Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 29892015) Carotid intima media thickness (mean) ( 31801372) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Heel bone mineral density ( 30598549) PR interval ( 32439900) QRS duration ( 30012220) Systolic blood pressure ( 30578418)	Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)
Interacting Genes		88 interacting genes: ADAMTSL4 ADRA2C AGR2 ASB12 BHLHB9 BLZF1 C11orf1 CCDC33 CERCAM CFP CTAG1A CTAG1B CYSRT1 DMAC2L ECM1 FTO GOLGA6A GSC2 HDHD3 IKZF3 KLHL20 KRT27 KRT31 KRT34 KRT35 KRT38 KRT39 KRT40 KRT85 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-1 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-11 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LHX3 LHX4 MAGEA6 MDFI MEOX2 MGAT5B MKRN3 MORN3 NBPF19 NOTCH2NLA OIP5 PAX5 PBX4 PFDN5 PLSCR4 POF1B POU2AF1 RGS20 RSPO4 SLC15A2 SPRY4 TACC3 TADA2A TCF4 TEKT1 TEKT5 TENT5B TEPSIN TIMM10B TRAF1 TRIB3 TRIM42 TRIM54 TRIM69 TXNDC11 UBE3A USHBP1 WFDC5 WWOX YPEL3 ZNF341	78 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL C2CD6 CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GAS8 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LHX1 LMX1A MAPK9 NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TLE5 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 YY1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76
Entrez ID		340359	8022
HPRD ID		19276	02783
Ensembl ID		ENSG00000175946	ENSG00000107187
Uniprot IDs		Q2WGJ6	F1T0D5 F1T0D9 Q9UBR4
PDB IDs
Enriched GO Terms of Interacting Partners?
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