CLEC4G and CAPN1

Data Source:
BioGRID (two hybrid)

		CLEC4G	CAPN1
Description		C-type lectin domain family 4 member G	calpain 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Virus Receptor Activity Protein Binding Mannose Binding Polysaccharide Binding Fructose Binding Carbohydrate Derivative Binding Glycosylated Region Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of T Cell Proliferation Viral Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Viral Life Cycle	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Blood protein levels ( 28240269) Post bronchodilator FEV1 ( 26634245)	Urate levels ( 31578528)
Interacting Genes		26 interacting genes: APOA1 APOH ARL13B ARSA ASGR1 AZU1 CAPN1 CPLX4 CPN1 EBAG9 EIF6 FAM209A FTL GEM IFI35 LRRC4C MAP3K11 MT-CO1 NUP214 PKLR PRDX1 PTPN5 RPSA SHBG SIGLEC12 WBP2	54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		339390	823
HPRD ID		16721	00253
Ensembl ID		ENSG00000182566	ENSG00000014216
Uniprot IDs		B7ZKQ2 Q08G24 Q6UXB4 Q6XYD1	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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