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IARS1 and MIR1-1
Data Source:
BioGRID
(unspecified method)
IARS1
MIR1-1
Description
isoleucyl-tRNA synthetase 1
microRNA 1-1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Extracellular Exosome
Extracellular Space
Molecular Function
TRNA Binding
Aminoacyl-tRNA Editing Activity
Isoleucine-tRNA Ligase Activity
Protein Binding
ATP Binding
GTPase Binding
RNA Polymerase II Complex Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
Osteoblast Differentiation
TRNA Aminoacylation For Protein Translation
Isoleucyl-tRNA Aminoacylation
Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Fate Commitment
Positive Regulation Of Heart Rate
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Myotube Differentiation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Endothelial Cell Differentiation
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Sarcomere Organization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Ventricular Septum Morphogenesis
Positive Regulation Of Cardiac Muscle Contraction
Cell Migration Involved In Coronary Vasculogenesis
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Canonical Wnt Signaling Pathway
Reversible Differentiation
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Negative Regulation Of Cardiac Conduction
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Mesoderm Formation
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Differentiation
Negative Regulation Of Myoblast Proliferation
Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Drugs
Isoleucine
Diseases
GWAS
Prostate cancer (
23535732
)
Subjective response to lithium treatment in bipolar disorder (
26503763
)
Interacting Genes
76 interacting genes:
APP
AR
CDC42
DUX4
EPRS1
ERBB2
GARS1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR25
MIR29A
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
SUMO2
89 interacting genes:
ADARB1
APOBEC3B
AQR
ATXN2L
C1QBP
CPSF7
CRTAP
DARS1
DDX1
DDX21
DDX3X
DHX36
DHX37
EDC4
EIF2AK2
EPRS1
ERAL1
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KIN
KNOP1
LARP7
LARS1
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI2
NOL6
NONO
NUDT21
NUFIP2
PDCD11
PRMT1
PTBP1
PTBP3
PUF60
PUM1
PURA
QARS1
RARS1
RBFOX2
RBM14
RBM4
RTCA
RTCB
SART3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SUGP1
SUGP2
SYNCRIP
TAF15
TRA2A
TRA2B
TRIM25
TRIM71
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZFR
ZNF346
ZNF385A
Entrez ID
3376
406904
HPRD ID
02832
Ensembl ID
ENSG00000196305
ENSG00000199017
Uniprot IDs
P41252
Q6P0M4
Q7L4K8
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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