MIR1-1 and ADARB1

Data Source:
BioGRID (unspecified method)

		MIR1-1	ADARB1
Description		microRNA 1-1	adenosine deaminase RNA specific B1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse
	Molecular Function	RNA Polymerase II Complex Binding MRNA Binding Involved In Posttranscriptional Gene Silencing	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Protein Binding TRNA-specific Adenosine Deaminase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation	Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process
Pathways			C6 deamination of adenosine Formation of editosomes by ADAR proteins
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Adult body size ( 32376654) Body mass index ( 28892062 25673413) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)
Interacting Genes		89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A	54 interacting genes: APP EHHADH EIF2AK2 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF PIN1 PNPT1 PRKRA STAU1 STOX1 STRBP TARBP2 TCEANC UBE2I ZMAT4 ZNF346
Entrez ID		406904	104
HPRD ID			06777
Ensembl ID		ENSG00000199017	ENSG00000197381
Uniprot IDs			P78563
PDB IDs			1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF
Enriched GO Terms of Interacting Partners?
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