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MIR1-1 and PRMT1
Data Source:
BioGRID
(unspecified method)
MIR1-1
PRMT1
Description
microRNA 1-1
protein arginine methyltransferase 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Methylosome
Molecular Function
RNA Polymerase II Complex Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
RNA Binding
Protein Binding
Methyltransferase Activity
N-methyltransferase Activity
Protein Methyltransferase Activity
Methyl-CpG Binding
Protein-arginine N-methyltransferase Activity
Enzyme Binding
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Identical Protein Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Mitogen-activated Protein Kinase P38 Binding
S-adenosyl-L-methionine Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Fate Commitment
Positive Regulation Of Heart Rate
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Myotube Differentiation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Endothelial Cell Differentiation
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Sarcomere Organization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Ventricular Septum Morphogenesis
Positive Regulation Of Cardiac Muscle Contraction
Cell Migration Involved In Coronary Vasculogenesis
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Canonical Wnt Signaling Pathway
Reversible Differentiation
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Negative Regulation Of Cardiac Conduction
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Mesoderm Formation
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Differentiation
Negative Regulation Of Myoblast Proliferation
Positive Regulation Of Skeletal Muscle Cell Differentiation
In Utero Embryonic Development
Protein Methylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Histone Methylation
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Neuron Projection Development
Histone H4-R3 Methylation
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Hemoglobin Biosynthetic Process
Protein Homooligomerization
Positive Regulation Of P38MAPK Cascade
Pathways
RMTs methylate histone arginines
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Drugs
S-adenosyl-L-homocysteine
Diseases
GWAS
Prostate cancer (
23535732
)
Subjective response to lithium treatment in bipolar disorder (
26503763
)
Schizophrenia (
29483656
)
Interacting Genes
89 interacting genes:
ADARB1
APOBEC3B
AQR
ATXN2L
C1QBP
CPSF7
CRTAP
DARS1
DDX1
DDX21
DDX3X
DHX36
DHX37
EDC4
EIF2AK2
EPRS1
ERAL1
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KIN
KNOP1
LARP7
LARS1
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI2
NOL6
NONO
NUDT21
NUFIP2
PDCD11
PRMT1
PTBP1
PTBP3
PUF60
PUM1
PURA
QARS1
RARS1
RBFOX2
RBM14
RBM4
RTCA
RTCB
SART3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SUGP1
SUGP2
SYNCRIP
TAF15
TRA2A
TRA2B
TRIM25
TRIM71
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZFR
ZNF346
ZNF385A
151 interacting genes:
AR
ARPC3
ASH2L
AXIN1
BRCA1
BTG1
BTG2
C4orf17
CAPRIN1
CDC37
CEP162
CIRBP
CNOT8
COIL
DAXX
DCAF16
DCAF8
DHX9
EIF4A1
EP300
ESR1
EWSR1
FAM83D
FAM9A
FBL
FBXL17
FBXO7
FGF2
FLII
FUS
GLI1
GPATCH2L
GRHL3
GRIP1
H3C1
H4-16
H4C14
HABP4
HNF4A
HNRNPA1
HNRNPK
HNRNPR
HNRNPU
HNRNPUL1
HROB
IDH3B
IFNAR1
IGSF21
ILF3
KHDRBS1
KHDRBS2
KHDRBS3
LRIF1
MBP
MECOM
MED31
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR138-1
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR206
MIR20A
MIR20B
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR34A
MIR34C
MIR363
MIR451A
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MLST8
NCOA1
NCOA2
NCOA3
NOL4
NRIP1
NTAQ1
OFCC1
PPARA
PRMT8
QKI
RBM15
RELA
RNF187
RUNX1
S100A8
SAMD3
SHLD1
SIRT1
SPAG8
SPEG
SPSB1
SPSB2
STAT1
STAT5A
STUB1
SUPT5H
TBX6
TERF2
THRB
TP53
TRIM48
UBE4B
VHL
VPS72
WDFY3
WDR33
YLPM1
YWHAG
ZBTB14
ZMYM5
ZNF451
Entrez ID
406904
3276
HPRD ID
04257
Ensembl ID
ENSG00000199017
ENSG00000126457
Uniprot IDs
Q99873
PDB IDs
6NT2
Enriched GO Terms of Interacting Partners
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