IARS1 and MIR20A

Data Source:
BioGRID (unspecified method)

		IARS1	MIR20A
Description		isoleucyl-tRNA synthetase 1	microRNA 20a
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Exosome	Extracellular Space Extracellular Vesicle
	Molecular Function	TRNA Binding Aminoacyl-tRNA Editing Activity Isoleucine-tRNA Ligase Activity Protein Binding ATP Binding GTPase Binding	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Osteoblast Differentiation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Outflow Tract Morphogenesis Negative Regulation Of Protein Kinase Activity Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Interleukin-17 Production Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Adhesion Molecule Production Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cardioblast Proliferation Positive Regulation Of Pulmonary Blood Vessel Remodeling
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs		Isoleucine
Diseases
GWAS
Interacting Genes		76 interacting genes: APP AR CDC42 DUX4 EPRS1 ERBB2 GARS1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I SUMO2	73 interacting genes: AIMP2 APOBEC3B C1QBP CRTAP DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 DZIP3 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC LSM10 LSM11 MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBM14 RBM4 RTCB SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TIAL1 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3 ZNF346
Entrez ID		3376	406982
HPRD ID		02832
Ensembl ID		ENSG00000196305	ENSG00000283762
Uniprot IDs		P41252 Q6P0M4 Q7L4K8
PDB IDs
Enriched GO Terms of Interacting Partners?
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