Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
HNRNPD and MAP2K1
Data Source:
BioGRID
(two hybrid)
HNRNPD
MAP2K1
Description
heterogeneous nuclear ribonucleoprotein D
mitogen-activated protein kinase kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Synapse
Ribonucleoprotein Complex
Nucleus
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Plasma Membrane
Focal Adhesion
Molecular Function
Minor Groove Of Adenine-thymine-rich DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
Transcription Factor Binding
MRNA 3'-UTR AU-rich Region Binding
Telomeric DNA Binding
Histone Deacetylase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
MAP-kinase Scaffold Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein Serine/threonine Kinase Activator Activity
Protein N-terminus Binding
Scaffold Protein Binding
Biological Process
MRNA Splicing, Via Spliceosome
Liver Development
Regulation Of Transcription, DNA-templated
RNA Processing
RNA Catabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Cerebellum Development
Regulation Of Telomere Maintenance
Regulation Of Circadian Rhythm
Regulation Of MRNA Stability
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
MRNA Stabilization
Response To Calcium Ion
Response To Electrical Stimulus
3'-UTR-mediated MRNA Destabilization
Cellular Response To Amino Acid Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Nitric Oxide
Circadian Regulation Of Translation
Response To Rapamycin
Positive Regulation Of Telomere Capping
Response To Sodium Phosphate
Cellular Response To Putrescine
Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity
Hepatocyte Dedifferentiation
MAPK Cascade
Activation Of MAPK Activity
Protein Phosphorylation
Chemotaxis
Cell Cycle Arrest
Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cerebellar Cortex Formation
Neuron Differentiation
Keratinocyte Differentiation
Thyroid Gland Development
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transcription, DNA-templated
Thymus Development
Regulation Of Axon Regeneration
Cell Motility
Positive Regulation Of Axonogenesis
Bergmann Glial Cell Differentiation
Face Development
Trachea Formation
Epithelial Cell Proliferation Involved In Lung Morphogenesis
Placenta Blood Vessel Development
Labyrinthine Layer Development
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Golgi Inheritance
Cellular Senescence
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Regulation Of Early Endosome To Late Endosome Transport
Pathways
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
MAPK3 (ERK1) activation
Frs2-mediated activation
Signal transduction by L1
Uptake and function of anthrax toxins
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
Drugs
Artenimol
K-252a
5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Cobimetinib
Bosutinib
(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
PD-0325901
N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
Trametinib
Selumetinib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Chronotype (
30696823
)
Coronary artery disease (
32469254
33020668
)
Morning person (
30696823
)
Refractive error (
32231278
)
Prostate cancer (
29892016
)
Testicular germ cell tumor (
28604728
28604732
)
Interacting Genes
87 interacting genes:
ABCC10
ACTB
ADGRE5
ARF4
B3GAT3
BCL2
BET1L
BRCA1
C1QBP
CAPN1
CD81
CINP
COG7
COL18A1
CSDE1
CTSB
CUTA
DGCR2
DHX30
DMAC1
EEF2
ERG
ESR1
EXOSC4
FBXL15
FLNA
GSK3B
GTF3C3
GTSE1
GUK1
HBZ
HDAC1
HIRA
HMGA1
HNRNPF
HNRNPH3
HSPA4
HSPB1
HSPB2
IGF2BP2
IL7R
IMMP2L
IMMT
ING4
LDHA
LSM5
MAP2K1
MAPK6
MEOX2
MPP1
MTA2
NTMT1
P4HB
PABPC1
PCBP1
PCBP2
PCSK7
PDLIM7
PEX10
PPOX
PRDX3
PRKACA
PTBP2
PYCR1
RALY
RPSA
SAFB
SDF2
SEPTIN9
SF3B4
SFN
SHISA5
SLC27A5
SLC3A2
SNAPC4
SNRPC
SREK1
SUMO4
SYNCRIP
TNPO1
TRN-GTT2-7
TSEN34
UBE2I
UQCRC1
VEGFA
VHL
YBX1
67 interacting genes:
APC
ARAF
AURKA
BANP
BAX
BIRC6
BMPR1A
BRAF
BUB1
CASP9
CDH1
CDK5
CDKN2A
CPNE1
CPNE4
CTNNA1
EGFR
ELK1
EP300
ERBB2
FBXW7
GRB10
HNRNPD
HRAS
KAT7
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MBP
MLH3
MSH6
MYC
ODC1
PAK1
PARVA
PDGFRL
PEBP1
PEBP4
PIK3CA
PLEKHF2
PLK3
PPARG
PRKCI
PRKCZ
PTPRJ
RAF1
RPS6KA2
RPS6KA4
SMAD2
SRC
STK11
TCP11
TGFBR2
TLR2
TRAF3
TRAF6
TRIB1
UBE2I
UBE2L3
WNK1
Entrez ID
3184
5604
HPRD ID
03206
01469
Ensembl ID
ENSG00000138668
ENSG00000169032
Uniprot IDs
A0A024RDB4
A0A024RDF4
A1LU37
Q14103
A4QPA9
B4DFY5
H3BRW9
Q02750
PDB IDs
1HD0
1HD1
1IQT
1WTB
1X0F
2Z5N
5IM0
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5BX0
5EYM
5HZE
5YT3
6NYB
6PP9
6Q0J
6Q0T
6U2G
6X2P
6X2S
6X2X
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?