DNAJA1 and CAV2

Data Source:
BioGRID (two hybrid)

		DNAJA1	CAV2
Description		DnaJ heat shock protein family (Hsp40) member A1	caveolin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Hsp70 Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding C3HC4-type RING Finger Domain Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Flagellated Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of ATPase Activity DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process Vesicle Docking Skeletal Muscle Fiber Development Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly Basement Membrane Organization
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS			Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Atrial fibrillation ( 30061737 29892015) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 28073927) Ischemic stroke (cardioembolic) ( 29531354) P wave duration ( 28794112) PR interval ( 29127183 30046033 32439900 20062060 25035420) Refractive error ( 32231278) TPE interval (resting) ( 32386560)
Interacting Genes		24 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LINC01554 LSM2 NELFCD NUDT3 PAXIP1 PGR PTEN PTTG1 SUMO2 SUMO4 TM4SF1 TXN	12 interacting genes: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SDCBP SRC
Entrez ID		3301	858
HPRD ID		04159	03029
Ensembl ID		ENSG00000086061	ENSG00000105971
Uniprot IDs		B7Z5C0 P31689	P51636 Q53X57
PDB IDs		2LO1 2M6Y 6E8M
Enriched GO Terms of Interacting Partners?
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