ACACA and CHGB

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACACA	CHGB
Description		acetyl-CoA carboxylase alpha	chromogranin B
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytosol Actin Cytoskeleton	Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule
	Molecular Function	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	Hormone Activity Protein Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process	Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Biotin
Diseases
GWAS		Ovarian cancer ( 23535730)	Metabolite levels ( 23823483) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		11 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 PRKAA1 PRKAA2 PRKAB1 PRKAG1	34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		31	1114
HPRD ID		01938	07512
Ensembl ID		ENSG00000278540	ENSG00000089199
Uniprot IDs		A0A024R0Y2 Q13085 Q7Z5W8	P05060
PDB IDs		2YL2 3COJ 4ASI 6G2D 6G2H 6G2I
Enriched GO Terms of Interacting Partners?
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