ACACA and PRKAB1

Data Source:
BioGRID (enzymatic study)

		ACACA	PRKAB1
Description		acetyl-CoA carboxylase alpha	protein kinase AMP-activated non-catalytic subunit beta 1
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GO Annotations	Cellular Component	Fibrillar Center Cytosol Actin Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Biotin	Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Ovarian cancer ( 23535730)	Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 PRKAA1 PRKAA2 PRKAB1 PRKAG1	12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2
Entrez ID		31	5564
HPRD ID		01938	04116
Ensembl ID		ENSG00000278540	ENSG00000111725
Uniprot IDs		A0A024R0Y2 Q13085 Q7Z5W8	A0A024RBN1 Q9Y478
PDB IDs		2YL2 3COJ 4ASI 6G2D 6G2H 6G2I	4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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