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CHGB and POLD1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CHGB
POLD1
Description
chromogranin B
DNA polymerase delta 1, catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Endoplasmic Reticulum Lumen
Secretory Granule
Nucleotide-excision Repair Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Membrane
Aggresome
Delta DNA Polymerase Complex
Molecular Function
Hormone Activity
Protein Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
3'-5'-exodeoxyribonuclease Activity
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Signal Transduction
Post-translational Protein Modification
Cellular Protein Metabolic Process
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA-dependent DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Response To UV
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Cellular Response To UV
DNA Damage Response, Detection Of DNA Damage
DNA Replication Proofreading
Fatty Acid Homeostasis
Error-free Translesion Synthesis
DNA Biosynthetic Process
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Cytosolic iron-sulfur cluster assembly
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Uterine fibroid number (single vs multiple) (
30196971
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Obesity-related traits (
23251661
)
Interacting Genes
34 interacting genes:
ACACA
ANXA7
APP
ATXN2
CBFB
CCDC92
CDKN1A
FGFR3
LRRK1
LRRK2
MARK3
MFHAS1
MGLL
MOGS
OGG1
PKN2
POLD1
POLR2E
PRAG1
PTEN
RAC2
RAP1B
RCC1
RXRG
S100A8
SAFB2
SLC25A6
TAZ
TK1
TUBB2A
TWF2
UBQLN1
UBTF
YLPM1
22 interacting genes:
ADAMTSL4
ATR
CCND3
CCNE1
CDK2
CDK4
CEP126
CHGB
GINS4
LASP1
MCPH1
PCNA
POLD2
POLD3
POLD4
SUMO2
TERF2IP
TREX2
TRIM55
WRNIP1
XRCC5
YPEL3
Entrez ID
1114
5424
HPRD ID
07512
08882
Ensembl ID
ENSG00000089199
ENSG00000062822
Uniprot IDs
P05060
A0A024R4F4
A0A087WYJ2
M0R2B7
P28340
Q308M6
Q59FA0
PDB IDs
6S1M
6S1N
6S1O
6TNY
6TNZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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