TAX1BP3 and PLK4

Data Source:
BioGRID (two hybrid)

		TAX1BP3	PLK4
Description		Tax1 binding protein 3	polo like kinase 4
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GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Intracellular Membrane-bounded Organelle Extracellular Exosome	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	Protein Binding Beta-catenin Binding Protein C-terminus Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Activation Of GTPase Activity Negative Regulation Of Protein Localization To Cell Surface	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		RHO GTPases Activate Rhotekin and Rhophilins	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		13 interacting genes: ARNT2 CDK5RAP3 CTNNB1 DTX1 GATA1 GLS GLS2 PLK4 RNF183 RTKN STAU1 TCEA2 TRIM29	22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		30851	10733
HPRD ID		18160	10387
Ensembl ID		ENSG00000213977	ENSG00000142731
Uniprot IDs		A0A087X282 O14907	O00444
PDB IDs		2KG2 2L4S 2L4T 2VZ5 3GJ9 3SFJ 4E3B 4NNL 4NNM	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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