Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
HDAC1 and ZBTB16
Data Source:
HPRD
(in vitro, in vivo)
HDAC1
ZBTB16
Description
histone deacetylase 1
zinc finger and BTB domain containing 16
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Sin3 Complex
NuRD Complex
Protein-containing Complex
Neuronal Cell Body
Nucleus
Cytosol
Plasma Membrane
Nuclear Body
PML Body
Nuclear Speck
Transcription Repressor Complex
Protein-containing Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
P53 Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Deacetylase Activity
Enzyme Binding
Nucleosomal DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Activating Transcription Factor Binding
Krueppel-associated Box Domain Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
E-box Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Heterochromatin Assembly
Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Endoderm Development
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Negative Regulation Of Gene Expression
Negative Regulation Of Myotube Differentiation
Histone Deacetylation
Hippocampus Development
Neuron Differentiation
Circadian Regulation Of Gene Expression
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation By Host Of Viral Transcription
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Endopeptidase Activity
Negative Regulation Of Androgen Receptor Signaling Pathway
Hair Follicle Placode Formation
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Histone H3 Deacetylation
Histone H4 Deacetylation
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Amyloid-beta Clearance
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Mesonephros Development
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Central Nervous System Development
Negative Regulation Of Cell Population Proliferation
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Protein Ubiquitination
Hemopoiesis
Myeloid Cell Differentiation
Positive Regulation Of Chondrocyte Differentiation
Protein Localization To Nucleus
Embryonic Hindlimb Morphogenesis
Forelimb Morphogenesis
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Male Germ-line Stem Cell Asymmetric Division
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Positive Regulation Of Cartilage Development
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
p75NTR negatively regulates cell cycle via SC1
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Deactivation of the beta-catenin transactivating complex
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Repression of WNT target genes
Repression of WNT target genes
Regulation of TP53 Activity through Acetylation
G1/S-Specific Transcription
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Arsenic trioxide
Zinc
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Fingolimod
Mocetinostat
Abexinostat
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Skeletal defects, genital hypoplasia, and mental retardation
Acute myeloid leukemia (AML)
GWAS
Basophil count (
32888494
)
Chronotype (
30696823
)
Conduct disorder (maternal expressed emotions interaction) (
18846501
)
Corneal astigmatism (
29422769
)
Diisocyanate-induced asthma (
25918132
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-glioblastoma glioma (
28346443
26424050
)
Paneth cell defects in Crohn's disease (
28352666
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Polycystic ovary syndrome (
26284813
30566500
)
Red blood cell count (
32888494
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Urinary albumin-to-creatinine ratio (
32600054
)
White blood cell count (
32888494
27863252
)
Interacting Genes
189 interacting genes:
APEX1
AR
ARID4A
ATF3
ATRX
BAZ2A
BCL11A
BCL3
BCL6
BCL6B
BCOR
BHLHE40
BRCA1
BRMS1
BRMS1L
BUB1
BUB1B
BUB3
CBFA2T3
CCN5
CDC20
CDH1
CDKN1A
CDYL
CHD1
CHD4
CHFR
CIITA
CREBBP
CREM
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDB2
DDX17
DHX30
DNMT1
DNMT3A
DNMT3B
DNMT3L
EED
EID2
EID2B
ELK1
ENO1
EP300
ERCC6
EZH2
FKBP3
FOXG1
FRA10F
GATA3
GCM1
GPS2
H2AC1
H3-4
H3C1
HBP1
HDAC2
HDAC3
HDAC7
HDAC9
HELLS
HEY2
HIC1
HIF1A
HIF1AN
HNRNPD
HR
HUS1
IKZF1
ING1
IRF5
JDP2
KAT5
KCTD11
KDM1A
KLF1
KLF11
KLF4
KLF5
LCOR
MAD1L1
MAGEA1
MBD2
MBD3
MBD3L2
MBD4
MDM2
MECOM
MECP2
MEN1
MIER1
MORF4L2
MTA1
MXD1
MYOD1
NCOR2
NFE4
NFKB1
NFKBIA
NKX2-5
NKX3-2
NR1D2
NR2E3
NR2F2
NR3C1
NRIP1
NUP98
PARP1
PCNA
PEX14
PHB
PHB2
PHF12
PHF21A
PIAS3
PIAS4
PITX2
PML
PPARD
PPARG
PPP2R1B
PRKACA
PRKG1
PRRG4
PTMA
RAD9A
RAP1A
RARA
RB1
RBBP4
RBBP7
RBL1
RBL2
RBP1
RBPJ
RELA
REPIN1
RFC1
RFC4
RUNX1T1
RUNX3
RUVBL2
SALL1
SAP18
SAP30
SATB1
SATB2
SENP1
SERPINB5
SETDB1
SIN3A
SIN3B
SMAD2
SMAD3
SOX6
SP1
SP3
SPEN
SPI1
STAT2
STAT3
SUDS3
SUMO2
SUV39H1
SYK
TAB2
TAL1
TFCP2
TGIF1
TGIF2
THAP11
TNIP1
TOP2A
TOP2B
TP53
TPD52L1
TRIM27
TXNIP
UBE2I
USP38
USP43
VHL
ZBTB16
ZMYND11
ZNF76
154 interacting genes:
ACP5
ADAMTS4
AGTR2
AMOTL2
ANAPC5
ANXA7
AR
ATP6AP2
ATP7B
BCL6
BLZF1
BMI1
CARD9
CASP3
CCDC130
CCDC85B
CCHCR1
CD81
CDK1
CDK4
CDKN1A
CEBPA
CEP70
CEP72
CFH
CIDEA
COG6
COQ6
CTDSP1
DLST
DNAAF5
DNM2
DPM1
EEF1A1
EFHC2
EIF2S2
ENOX1
EP300
EPN1
ERVK-6
ESR1
FAM217B
FAM90A1
FCHO1
FHL2
FHL5
FSHR
GATA1
GATA2
GCSH
GNE
GOLGA2
GOLGA6L9
GPANK1
GRB7
GSTM4
HBEGF
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
HDAC6
HDAC7
HDAC9
HDX
HOXA1
HOXC5
HSF2BP
ICAM3
IL6
KIAA1549
KIFC3
KRT40
KRTAP4-12
LAMTOR5
LDOC1
LMTK3
LRIG1
LSM2
LYAR
MAGEA11
MAP3K3
MCUB
MEOX2
MID2
MTUS2
MX1
MYLIP
NCOR1
NCOR2
NFKBID
NME4
NR3C1
OSBPL3
PAFAH1B3
PARP1
PGAM5
PHF1
PIAS2
PIBF1
PLSCR1
PMAIP1
PML
PNRC2
PRKAR1B
PSMD11
PSMD2
QTRT1
RAB27A
RAB3IP
RARA
RB1
REL
RFLNB
RINT1
RUNX1T1
RXRA
SH2D4A
SIN3A
SIN3B
SMAD3
SMN1
SP1
SPOP
SPRY2
SUMO1
TAB2
TERF1
THNSL2
TK1
TLE5
TOLLIP
TRAF1
TRAF2
TRAF4
TRIM21
TRIM23
TRIM27
TRIM54
TTC23
TXNIP
UBE2I
VDR
VTA1
WASHC1
WDR33
ZBTB32
ZBTB42
ZNF24
ZNF281
ZNF552
ZNF620
ZNF655
Entrez ID
3065
7704
HPRD ID
03143
11762
Ensembl ID
ENSG00000116478
ENSG00000109906
Uniprot IDs
Q13547
Q6IT96
A0A024R3C6
Q05516
PDB IDs
1TYI
4BKX
5ICN
6Z2J
6Z2K
1BUO
1CS3
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?