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HDAC1 and RB1
Data Source:
BioGRID
(fluorescent resonance energy transfer, affinity chromatography technology)
HPRD
(in vivo)
HDAC1
RB1
Description
histone deacetylase 1
RB transcriptional corepressor 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Sin3 Complex
NuRD Complex
Protein-containing Complex
Neuronal Cell Body
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Spindle
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
P53 Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Deacetylase Activity
Enzyme Binding
Nucleosomal DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Activating Transcription Factor Binding
Krueppel-associated Box Domain Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
E-box Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Heterochromatin Assembly
Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Endoderm Development
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Negative Regulation Of Gene Expression
Negative Regulation Of Myotube Differentiation
Histone Deacetylation
Hippocampus Development
Neuron Differentiation
Circadian Regulation Of Gene Expression
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation By Host Of Viral Transcription
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Endopeptidase Activity
Negative Regulation Of Androgen Receptor Signaling Pathway
Hair Follicle Placode Formation
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Histone H3 Deacetylation
Histone H4 Deacetylation
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Amyloid-beta Clearance
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Tissue Homeostasis
Aortic Valve Morphogenesis
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Cell Cycle Arrest
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Viral Process
Cell Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cohesin Loading
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Extracellular Matrix Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
p75NTR negatively regulates cell cycle via SC1
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Deactivation of the beta-catenin transactivating complex
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Repression of WNT target genes
Repression of WNT target genes
Regulation of TP53 Activity through Acetylation
G1/S-Specific Transcription
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Drugs
Arsenic trioxide
Zinc
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Fingolimod
Mocetinostat
Abexinostat
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Insulin human
Insulin pork
Diseases
Bladder cancer
Small cell lung cancer
Glioma
Osteosarcoma
Breast cancer
Esophageal cancer
Hepatocellular carcinoma
Chronic myeloid leukemia (CML)
GWAS
Birth weight (
31043758
27680694
)
Chronic kidney disease (
26420894
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
189 interacting genes:
APEX1
AR
ARID4A
ATF3
ATRX
BAZ2A
BCL11A
BCL3
BCL6
BCL6B
BCOR
BHLHE40
BRCA1
BRMS1
BRMS1L
BUB1
BUB1B
BUB3
CBFA2T3
CCN5
CDC20
CDH1
CDKN1A
CDYL
CHD1
CHD4
CHFR
CIITA
CREBBP
CREM
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDB2
DDX17
DHX30
DNMT1
DNMT3A
DNMT3B
DNMT3L
EED
EID2
EID2B
ELK1
ENO1
EP300
ERCC6
EZH2
FKBP3
FOXG1
FRA10F
GATA3
GCM1
GPS2
H2AC1
H3-4
H3C1
HBP1
HDAC2
HDAC3
HDAC7
HDAC9
HELLS
HEY2
HIC1
HIF1A
HIF1AN
HNRNPD
HR
HUS1
IKZF1
ING1
IRF5
JDP2
KAT5
KCTD11
KDM1A
KLF1
KLF11
KLF4
KLF5
LCOR
MAD1L1
MAGEA1
MBD2
MBD3
MBD3L2
MBD4
MDM2
MECOM
MECP2
MEN1
MIER1
MORF4L2
MTA1
MXD1
MYOD1
NCOR2
NFE4
NFKB1
NFKBIA
NKX2-5
NKX3-2
NR1D2
NR2E3
NR2F2
NR3C1
NRIP1
NUP98
PARP1
PCNA
PEX14
PHB
PHB2
PHF12
PHF21A
PIAS3
PIAS4
PITX2
PML
PPARD
PPARG
PPP2R1B
PRKACA
PRKG1
PRRG4
PTMA
RAD9A
RAP1A
RARA
RB1
RBBP4
RBBP7
RBL1
RBL2
RBP1
RBPJ
RELA
REPIN1
RFC1
RFC4
RUNX1T1
RUNX3
RUVBL2
SALL1
SAP18
SAP30
SATB1
SATB2
SENP1
SERPINB5
SETDB1
SIN3A
SIN3B
SMAD2
SMAD3
SOX6
SP1
SP3
SPEN
SPI1
STAT2
STAT3
SUDS3
SUMO2
SUV39H1
SYK
TAB2
TAL1
TFCP2
TGIF1
TGIF2
THAP11
TNIP1
TOP2A
TOP2B
TP53
TPD52L1
TRIM27
TXNIP
UBE2I
USP38
USP43
VHL
ZBTB16
ZMYND11
ZNF76
190 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FRK
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TP53
TRAP1
TRIM27
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
Entrez ID
3065
5925
HPRD ID
03143
01574
Ensembl ID
ENSG00000116478
ENSG00000139687
Uniprot IDs
Q13547
Q6IT96
A0A024RDV3
P06400
PDB IDs
1TYI
4BKX
5ICN
6Z2J
6Z2K
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
Enriched GO Terms of Interacting Partners
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