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HDAC1 and EZH2
Data Source:
BioGRID
(imaging technique)
HPRD
(in vivo)
HDAC1
EZH2
Description
histone deacetylase 1
enhancer of zeste 2 polycomb repressive complex 2 subunit
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Sin3 Complex
NuRD Complex
Protein-containing Complex
Neuronal Cell Body
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromatin Silencing Complex
Cytoplasm
ESC/E(Z) Complex
Pronucleus
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
P53 Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Deacetylase Activity
Enzyme Binding
Nucleosomal DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Activating Transcription Factor Binding
Krueppel-associated Box Domain Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
E-box Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Protein-lysine N-methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Chromatin DNA Binding
Histone Methyltransferase Activity
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H3-K27 Specific)
Primary MiRNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Heterochromatin Assembly
Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Endoderm Development
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Negative Regulation Of Gene Expression
Negative Regulation Of Myotube Differentiation
Histone Deacetylation
Hippocampus Development
Neuron Differentiation
Circadian Regulation Of Gene Expression
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation By Host Of Viral Transcription
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Endopeptidase Activity
Negative Regulation Of Androgen Receptor Signaling Pathway
Hair Follicle Placode Formation
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Histone H3 Deacetylation
Histone H4 Deacetylation
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Amyloid-beta Clearance
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation
Chromatin Organization
Chromatin Silencing At Telomere
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Gliogenesis
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Cardiac Muscle Hypertrophy In Response To Stress
Histone Methylation
Cerebellar Cortex Development
Hippocampus Development
B Cell Differentiation
Response To Estradiol
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Cellular Response To Trichostatin A
Hepatocyte Homeostasis
Regulation Of Circadian Rhythm
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of GTPase Activity
Negative Regulation Of Epidermal Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Cell Development
Rhythmic Process
Negative Regulation Of Striated Muscle Cell Differentiation
Cellular Response To Hydrogen Peroxide
G1 To G0 Transition
Negative Regulation Of G0 To G1 Transition
Histone H3-K27 Methylation
Protein Localization To Chromatin
Positive Regulation Of Protein Serine/threonine Kinase Activity
Liver Regeneration
Histone H3-K27 Trimethylation
Positive Regulation Of Dendrite Development
Positive Regulation Of Cell Cycle G1/S Phase Transition
Response To Tetrachloromethane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
p75NTR negatively regulates cell cycle via SC1
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Deactivation of the beta-catenin transactivating complex
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Repression of WNT target genes
Repression of WNT target genes
Regulation of TP53 Activity through Acetylation
G1/S-Specific Transcription
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Drugs
Arsenic trioxide
Zinc
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Fingolimod
Mocetinostat
Abexinostat
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Tazemetostat
CPI-1205
Diseases
GWAS
Chronotype (
30696823
)
Colorectal or endometrial cancer (
26621817
)
Crohn's disease (
28067908
)
Familial squamous cell lung carcinoma (
29924316
)
Height (
25282103
31562340
)
Inflammatory bowel disease (
28067908
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
)
Interacting Genes
189 interacting genes:
APEX1
AR
ARID4A
ATF3
ATRX
BAZ2A
BCL11A
BCL3
BCL6
BCL6B
BCOR
BHLHE40
BRCA1
BRMS1
BRMS1L
BUB1
BUB1B
BUB3
CBFA2T3
CCN5
CDC20
CDH1
CDKN1A
CDYL
CHD1
CHD4
CHFR
CIITA
CREBBP
CREM
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDB2
DDX17
DHX30
DNMT1
DNMT3A
DNMT3B
DNMT3L
EED
EID2
EID2B
ELK1
ENO1
EP300
ERCC6
EZH2
FKBP3
FOXG1
FRA10F
GATA3
GCM1
GPS2
H2AC1
H3-4
H3C1
HBP1
HDAC2
HDAC3
HDAC7
HDAC9
HELLS
HEY2
HIC1
HIF1A
HIF1AN
HNRNPD
HR
HUS1
IKZF1
ING1
IRF5
JDP2
KAT5
KCTD11
KDM1A
KLF1
KLF11
KLF4
KLF5
LCOR
MAD1L1
MAGEA1
MBD2
MBD3
MBD3L2
MBD4
MDM2
MECOM
MECP2
MEN1
MIER1
MORF4L2
MTA1
MXD1
MYOD1
NCOR2
NFE4
NFKB1
NFKBIA
NKX2-5
NKX3-2
NR1D2
NR2E3
NR2F2
NR3C1
NRIP1
NUP98
PARP1
PCNA
PEX14
PHB
PHB2
PHF12
PHF21A
PIAS3
PIAS4
PITX2
PML
PPARD
PPARG
PPP2R1B
PRKACA
PRKG1
PRRG4
PTMA
RAD9A
RAP1A
RARA
RB1
RBBP4
RBBP7
RBL1
RBL2
RBP1
RBPJ
RELA
REPIN1
RFC1
RFC4
RUNX1T1
RUNX3
RUVBL2
SALL1
SAP18
SAP30
SATB1
SATB2
SENP1
SERPINB5
SETDB1
SIN3A
SIN3B
SMAD2
SMAD3
SOX6
SP1
SP3
SPEN
SPI1
STAT2
STAT3
SUDS3
SUMO2
SUV39H1
SYK
TAB2
TAL1
TFCP2
TGIF1
TGIF2
THAP11
TNIP1
TOP2A
TOP2B
TP53
TPD52L1
TRIM27
TXNIP
UBE2I
USP38
USP43
VHL
ZBTB16
ZMYND11
ZNF76
77 interacting genes:
AKT1
AR
ATP1A1
ATP1B1
ATRX
BCL11A
BRCA1
C7orf25
CCDC85B
CDK2
CDK6
CDKN2B-AS1
CEP63
CRY2
DELEC1
DNAJB11
DNMT1
DNMT3A
DNMT3B
E2F6
EED
EHMT1
EPC2
FBXW7
GADD45G
GTF3C1
H1-1
H3-4
H3C1
HDAC1
HOTAIR
JAK2
KAT2B
KLHDC2
KRTAP10-9
LATS2
MAP3K20
MAP3K7
MAPK8IP2
MAPKAPK3
MED1
MELK
MUC1
MYCN
NINL
PFDN1
PHB2
PHF1
PIN4
PJA1
POLA2
PRDM14
PRMT5
PSMB6
RASA1
RBL2
RELA
RELB
RIN3
RPN2
RPS6KA5
SIRT1
SMN1
SMS
SMYD3
SUV39H1
SUZ12
TAF1D
TK1
TNFSF11
TRIM55
TRIM63
USP1
VAV1
WDR61
WSB2
ZMYND11
Entrez ID
3065
2146
HPRD ID
03143
03342
Ensembl ID
ENSG00000116478
ENSG00000106462
Uniprot IDs
Q13547
Q6IT96
A0A090N8E9
Q15910
S4S3R8
PDB IDs
1TYI
4BKX
5ICN
6Z2J
6Z2K
2C6V
4MI0
4MI5
5GSA
5H14
5H15
5H17
5H19
5H24
5H25
5HYN
5IJ7
5IJ8
5LS6
5U5T
5U62
5WG6
5WUK
6C23
6C24
6P5L
6U4Y
Enriched GO Terms of Interacting Partners
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