HMGCS2

Description		3-hydroxy-3-methylglutaryl-CoA synthase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Hydroxymethylglutaryl-CoA Synthase Activity Identical Protein Binding
	Biological Process	Acetyl-CoA Metabolic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Lipid Metabolic Process Ketone Body Biosynthetic Process
Pathways		PPARA activates gene expression Synthesis of Ketone Bodies
Drugs
Diseases		HMG-CoA synthase (HMGCS) deficiency
GWAS		Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Metabolite levels ( 23823483)
Novel Interacting Genes		2 novel interacting genes: ERO1B PTPN22
Interacting Genes		3 interacting genes: APP FBXO7 HSD17B10
Entrez ID		3158
HPRD ID		02580
Ensembl ID		ENSG00000134240
Uniprot IDs		A0A140VJL2 P54868
PDB IDs		2WYA
Enriched GO Terms of Interacting Partners?
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