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DNMT3L and GATA1
Data Source:
BioGRID
(pull down)
DNMT3L
GATA1
Description
DNA methyltransferase 3 like
GATA binding protein 1
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
ESC/E(Z) Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Repressor Complex
Protein-DNA Complex
Molecular Function
Protein Binding
Enzyme Activator Activity
Enzyme Binding
Metal Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Chromatin DNA Binding
Sequence-specific DNA Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
DNA Methylation
Regulation Of Gene Expression By Genetic Imprinting
Male Meiosis I
Spermatogenesis
DNA Methylation On Cytosine
DNA Methylation Involved In Gamete Generation
Negative Regulation Of Transcription, DNA-templated
Stem Cell Differentiation
Regulation Of Catalytic Activity
Negative Regulation Of DNA Methylation
Positive Regulation Of DNA Methylation
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Regulation Of Transcription By RNA Polymerase II
Cell-cell Signaling
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Definitive Erythrocyte Differentiation
Regulation Of Primitive Erythrocyte Differentiation
Erythrocyte Differentiation
Megakaryocyte Differentiation
Platelet Formation
Basophil Differentiation
Eosinophil Differentiation
Negative Regulation Of Bone Mineralization
Positive Regulation Of Osteoblast Proliferation
Embryonic Hemopoiesis
Eosinophil Fate Commitment
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Platelet Aggregation
Transcriptional Activation By Promoter-enhancer Looping
Dendritic Cell Differentiation
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
DNA methylation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Congenital dyserythropoietic anemias (CDAs)
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Interacting Genes
78 interacting genes:
-
ASH2L
ATF1
ATF2
ATF3
ATF4
BLZF1
CDX2
CREB1
CREBL2
CREM
DDIT3
DLX4
DMTF1
DNMT3A
DNMT3B
DR1
E2F3
E2F5
E2F6
EGR1
EGR2
EGR4
ESR1
ESR2
ETS1
F2RL1
FOS
FOSB
FOSL1
FOSL2
GATA1
GMEB1
GSK3B
GTF2H2
GTF2I
GTF3C5
H2AC20
H2BC21
H3C14
H4C14
HAND1
HAND2
HDAC1
HNF4G
HOXA5
HOXC11
ID1
JUN
JUNB
KLF12
LDB1
LHX2
MAFK
MECP2
MED7
MEF2A
MEF2D
NFIL3
NFKB1
NR1H2
NR1I2
NR1I3
NR2E1
NR3C1
NR6A1
NUDT21
PDZD4
PHPT1
RELA
RSL24D1
RXRA
SMAD1
SMAD3
SMAD4
TLE5
TP53
YY1
85 interacting genes:
AKT1
ARID1A
ARMC7
ATP6V0D1
BCL6
CASP3
CCDC24
CEBPE
CHRD
CREBBP
DGCR6L
DNMT3L
FANCG
FANCL
FBF1
FHL3
FLI1
FRS3
GLRX3
GOLGA2
GRAP2
HDAC3
HDAC4
HDAC5
HEMGN
HEXIM2
HEY1
HOXA1
HSPA4
KANK2
KRTAP10-5
KRTAP3-2
KRTAP4-11
KRTAP4-5
KRTAP9-2
LMO2
LZTS2
MAPK1
MAPK3
MAPK6
MDFI
MED1
MGAT5B
MKRN3
PITX1
PLSCR4
PML
PNMA1
PPP1R16B
PRKAA1
PRKAB2
PSMF1
RADIL
RAI1
RBPMS
RIN3
SMARCA4
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SMARCE1
SP1
SPI1
SPIB
SRA1
STAT3
TAF7
TAL1
TAX1BP3
TEKT4
TLE5
TNS2
TRAF1
TRIM25
TRIM29
TRIP6
USP7
ZBTB16
ZBTB22
ZDHHC17
ZFPM1
ZFPM2
ZNF521
ZZZ3
Entrez ID
29947
2623
HPRD ID
09417
02372
Ensembl ID
ENSG00000142182
ENSG00000102145
Uniprot IDs
Q9UJW3
P15976
PDB IDs
2PV0
2PVC
2QRV
4U7P
4U7T
5YX2
6BRR
6F57
6KDA
6KDB
6KDL
6KDP
6KDT
6U8P
6U8V
6U8W
6U8X
6U90
6U91
6W89
6W8B
6W8D
6W8J
6G0Q
Enriched GO Terms of Interacting Partners
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