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GATA1 and PITX1
Data Source:
BioGRID
(two hybrid)
GATA1
PITX1
Description
GATA binding protein 1
paired like homeodomain 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Repressor Complex
Protein-DNA Complex
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Chromatin DNA Binding
Sequence-specific DNA Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Regulation Of Transcription By RNA Polymerase II
Cell-cell Signaling
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Definitive Erythrocyte Differentiation
Regulation Of Primitive Erythrocyte Differentiation
Erythrocyte Differentiation
Megakaryocyte Differentiation
Platelet Formation
Basophil Differentiation
Eosinophil Differentiation
Negative Regulation Of Bone Mineralization
Positive Regulation Of Osteoblast Proliferation
Embryonic Hemopoiesis
Eosinophil Fate Commitment
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Platelet Aggregation
Transcriptional Activation By Promoter-enhancer Looping
Dendritic Cell Differentiation
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Skeletal System Development
Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Morphogenesis
Branchiomeric Skeletal Muscle Development
Pituitary Gland Development
Embryonic Hindlimb Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Cartilage Development
Pathways
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Congenital dyserythropoietic anemias (CDAs)
Congenital clubfoot; Congenital talipes equinovarus
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Atrial fibrillation (
29237688
)
Bulimia nervosa (
23568457
)
Colorectal cancer (
30529582
24836286
23263487
)
Colorectal cancer or advanced adenoma (
30510241
)
Height (
20881960
25429064
23563607
31562340
18391951
)
Immune response to anthrax vaccine (
22658931
)
Testicular germ cell tumor (
28604732
23666240
)
Interacting Genes
85 interacting genes:
AKT1
ARID1A
ARMC7
ATP6V0D1
BCL6
CASP3
CCDC24
CEBPE
CHRD
CREBBP
DGCR6L
DNMT3L
FANCG
FANCL
FBF1
FHL3
FLI1
FRS3
GLRX3
GOLGA2
GRAP2
HDAC3
HDAC4
HDAC5
HEMGN
HEXIM2
HEY1
HOXA1
HSPA4
KANK2
KRTAP10-5
KRTAP3-2
KRTAP4-11
KRTAP4-5
KRTAP9-2
LMO2
LZTS2
MAPK1
MAPK3
MAPK6
MDFI
MED1
MGAT5B
MKRN3
PITX1
PLSCR4
PML
PNMA1
PPP1R16B
PRKAA1
PRKAB2
PSMF1
RADIL
RAI1
RBPMS
RIN3
SMARCA4
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SMARCE1
SP1
SPI1
SPIB
SRA1
STAT3
TAF7
TAL1
TAX1BP3
TEKT4
TLE5
TNS2
TRAF1
TRIM25
TRIM29
TRIP6
USP7
ZBTB16
ZBTB22
ZDHHC17
ZFPM1
ZFPM2
ZNF521
ZZZ3
98 interacting genes:
ABHD11
AKAP8L
ALG13
ANKRD10
ARID5A
ATN1
BPIFA1
C10orf55
C11orf1
C19orf54
C1orf94
C9orf57
CDX4
CEACAM6
CYSRT1
DCTN3
DVL3
DZIP3
EFEMP2
EGR1
FAM168A
FAM168B
FOXO1
GATA1
GOLGA2
HGS
HOXA1
HSF4
HYI
IGFL2
IPO13
KLHL26
KRT34
KRT83
KRTAP13-1
KRTAP13-2
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LASP1
LZTS2
MAGED1
METTL27
MGAT5B
MSX2
MYH7B
MYOZ3
NEUROD1
NHLRC4
NID2
NR5A1
PFDN5
PLA2G10
PLEKHB2
PLSCR1
PLSCR3
POU1F1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB11
PTK6
RBPMS
RFX6
RHOXF2
RNF31
ROR2
SERGEF
SERPINE1
SIK1B
SLC15A2
SMARCA2
SPAG8
STH
TBX19
TBX22
TEKT5
TFAP2D
TLE5
TP53BP1
TRAF1
TRAPPC2
TRIM23
TSC1
UFSP1
UPF2
VGLL3
YPEL3
ZBTB32
ZNF34
Entrez ID
2623
5307
HPRD ID
02372
03688
Ensembl ID
ENSG00000102145
ENSG00000069011
Uniprot IDs
P15976
P78337
X5D9A5
PDB IDs
6G0Q
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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