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GATA1 and SMARCC2
Data Source:
BioGRID
(pull down)
GATA1
SMARCC2
Description
GATA binding protein 1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Repressor Complex
Protein-DNA Complex
Chromatin
Nucleoplasm
SWI/SNF Complex
Protein-containing Complex
NpBAF Complex
NBAF Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Chromatin DNA Binding
Sequence-specific DNA Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Transcription Coactivator Activity
Protein Binding
Nucleosomal DNA Binding
Histone Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Regulation Of Transcription By RNA Polymerase II
Cell-cell Signaling
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Definitive Erythrocyte Differentiation
Regulation Of Primitive Erythrocyte Differentiation
Erythrocyte Differentiation
Megakaryocyte Differentiation
Platelet Formation
Basophil Differentiation
Eosinophil Differentiation
Negative Regulation Of Bone Mineralization
Positive Regulation Of Osteoblast Proliferation
Embryonic Hemopoiesis
Eosinophil Fate Commitment
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Platelet Aggregation
Transcriptional Activation By Promoter-enhancer Looping
Dendritic Cell Differentiation
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
ATP-dependent Chromatin Remodeling
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Pathways
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Congenital dyserythropoietic anemias (CDAs)
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Asthma (
31619474
)
Refractive error (
32231278
)
Interacting Genes
85 interacting genes:
AKT1
ARID1A
ARMC7
ATP6V0D1
BCL6
CASP3
CCDC24
CEBPE
CHRD
CREBBP
DGCR6L
DNMT3L
FANCG
FANCL
FBF1
FHL3
FLI1
FRS3
GLRX3
GOLGA2
GRAP2
HDAC3
HDAC4
HDAC5
HEMGN
HEXIM2
HEY1
HOXA1
HSPA4
KANK2
KRTAP10-5
KRTAP3-2
KRTAP4-11
KRTAP4-5
KRTAP9-2
LMO2
LZTS2
MAPK1
MAPK3
MAPK6
MDFI
MED1
MGAT5B
MKRN3
PITX1
PLSCR4
PML
PNMA1
PPP1R16B
PRKAA1
PRKAB2
PSMF1
RADIL
RAI1
RBPMS
RIN3
SMARCA4
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SMARCE1
SP1
SPI1
SPIB
SRA1
STAT3
TAF7
TAL1
TAX1BP3
TEKT4
TLE5
TNS2
TRAF1
TRIM25
TRIM29
TRIP6
USP7
ZBTB16
ZBTB22
ZDHHC17
ZFPM1
ZFPM2
ZNF521
ZZZ3
26 interacting genes:
ARRB2
ATXN1
ATXN1L
BAZ1B
CSNK2A1
EWSR1
FUS
GATA1
IFTAP
ITCH
ITSN1
KLF1
KRT27
MCPH1
NOVA1
PEX14
PHYHIP
POLR2C
RAB1B
RELB
SMARCB1
SP1
SRGAP3
TAF15
TERF1
TERF2IP
Entrez ID
2623
6601
HPRD ID
02372
03437
Ensembl ID
ENSG00000102145
ENSG00000139613
Uniprot IDs
P15976
A0A024RB22
F8VXC8
Q8TAQ2
PDB IDs
6G0Q
6KAG
6LTH
6LTJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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