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GATA1 and PLSCR4
Data Source:
BioGRID
(two hybrid)
GATA1
PLSCR4
Description
GATA binding protein 1
phospholipid scramblase 4
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Repressor Complex
Protein-DNA Complex
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Chromatin DNA Binding
Sequence-specific DNA Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Phospholipid Scramblase Activity
Enzyme Binding
CD4 Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Regulation Of Transcription By RNA Polymerase II
Cell-cell Signaling
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Definitive Erythrocyte Differentiation
Regulation Of Primitive Erythrocyte Differentiation
Erythrocyte Differentiation
Megakaryocyte Differentiation
Platelet Formation
Basophil Differentiation
Eosinophil Differentiation
Negative Regulation Of Bone Mineralization
Positive Regulation Of Osteoblast Proliferation
Embryonic Hemopoiesis
Eosinophil Fate Commitment
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Platelet Aggregation
Transcriptional Activation By Promoter-enhancer Looping
Dendritic Cell Differentiation
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Plasma Membrane Phospholipid Scrambling
Cellular Response To Lipopolysaccharide
Pathways
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Congenital dyserythropoietic anemias (CDAs)
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
85 interacting genes:
AKT1
ARID1A
ARMC7
ATP6V0D1
BCL6
CASP3
CCDC24
CEBPE
CHRD
CREBBP
DGCR6L
DNMT3L
FANCG
FANCL
FBF1
FHL3
FLI1
FRS3
GLRX3
GOLGA2
GRAP2
HDAC3
HDAC4
HDAC5
HEMGN
HEXIM2
HEY1
HOXA1
HSPA4
KANK2
KRTAP10-5
KRTAP3-2
KRTAP4-11
KRTAP4-5
KRTAP9-2
LMO2
LZTS2
MAPK1
MAPK3
MAPK6
MDFI
MED1
MGAT5B
MKRN3
PITX1
PLSCR4
PML
PNMA1
PPP1R16B
PRKAA1
PRKAB2
PSMF1
RADIL
RAI1
RBPMS
RIN3
SMARCA4
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SMARCE1
SP1
SPI1
SPIB
SRA1
STAT3
TAF7
TAL1
TAX1BP3
TEKT4
TLE5
TNS2
TRAF1
TRIM25
TRIM29
TRIP6
USP7
ZBTB16
ZBTB22
ZDHHC17
ZFPM1
ZFPM2
ZNF521
ZZZ3
62 interacting genes:
ABHD17A
ADAMTSL4
APLN
ATP23
C11orf1
CES1
CLPP
CRCT1
DAZAP2
DDIT4L
EFEMP2
FCHO1
GATA1
HDHD3
HOXA1
INTS11
ITGB4
KLHL38
KPRP
KRT82
KRTAP1-5
KRTAP10-8
KRTAP19-1
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP3-1
KRTAP3-3
KRTAP4-12
KRTAP4-2
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
LCE1A
LCE1C
LCE2B
LCE5A
LPXN
MTUS2
NID2
NOTCH2NLA
OXER1
PCSK5
PLSCR1
RAMAC
RBP3
RBPMS
RPS27A
SLC15A2
SSC4D
TEKT5
TENM4
TRIM42
TRIP13
TSPAN4
UBA52
UBB
UBC
YPEL3
ZNF34
Entrez ID
2623
57088
HPRD ID
02372
07401
Ensembl ID
ENSG00000102145
ENSG00000114698
Uniprot IDs
P15976
E9PHR9
Q9NRQ2
PDB IDs
6G0Q
3Q5U
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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