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DNMT3L and E2F3
Data Source:
BioGRID
(pull down)
DNMT3L
E2F3
Description
DNA methyltransferase 3 like
E2F transcription factor 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
ESC/E(Z) Complex
Chromatin
Nucleus
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Protein Binding
Enzyme Activator Activity
Enzyme Binding
Metal Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
DNA Methylation
Regulation Of Gene Expression By Genetic Imprinting
Male Meiosis I
Spermatogenesis
DNA Methylation On Cytosine
DNA Methylation Involved In Gamete Generation
Negative Regulation Of Transcription, DNA-templated
Stem Cell Differentiation
Regulation Of Catalytic Activity
Negative Regulation Of DNA Methylation
Positive Regulation Of DNA Methylation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Import Into Nucleus
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Fat Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways
DNA methylation
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin D associated events in G1
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Metabolite levels (
23823483
)
Molybdenum levels (
26025379
)
Obesity-related traits (
23251661
)
Triglyceride levels (
32203549
)
Interacting Genes
78 interacting genes:
-
ASH2L
ATF1
ATF2
ATF3
ATF4
BLZF1
CDX2
CREB1
CREBL2
CREM
DDIT3
DLX4
DMTF1
DNMT3A
DNMT3B
DR1
E2F3
E2F5
E2F6
EGR1
EGR2
EGR4
ESR1
ESR2
ETS1
F2RL1
FOS
FOSB
FOSL1
FOSL2
GATA1
GMEB1
GSK3B
GTF2H2
GTF2I
GTF3C5
H2AC20
H2BC21
H3C14
H4C14
HAND1
HAND2
HDAC1
HNF4G
HOXA5
HOXC11
ID1
JUN
JUNB
KLF12
LDB1
LHX2
MAFK
MECP2
MED7
MEF2A
MEF2D
NFIL3
NFKB1
NR1H2
NR1I2
NR1I3
NR2E1
NR3C1
NR6A1
NUDT21
PDZD4
PHPT1
RELA
RSL24D1
RXRA
SMAD1
SMAD3
SMAD4
TLE5
TP53
YY1
25 interacting genes:
ATAD2
CCNA2
CDK3
CREBBP
DNMT3L
FHL2
FZR1
HCFC1
HELLS
MGA
MYBL2
PKIB
RB1
RNF144A
RYBP
SP1
SPIB
SRA1
TEAD3
TFDP1
TFDP2
TFE3
UCHL5
WNK1
YY1
Entrez ID
29947
1871
HPRD ID
09417
02693
Ensembl ID
ENSG00000142182
ENSG00000112242
Uniprot IDs
Q9UJW3
O00716
PDB IDs
2PV0
2PVC
2QRV
4U7P
4U7T
5YX2
6BRR
6F57
6KDA
6KDB
6KDL
6KDP
6KDT
6U8P
6U8V
6U8W
6U8X
6U90
6U91
6W89
6W8B
6W8D
6W8J
Enriched GO Terms of Interacting Partners
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