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CPSF1 and GLIS2
Data Source:
BioGRID
(two hybrid)
CPSF1
GLIS2
Description
cleavage and polyadenylation specific factor 1
GLIS family zinc finger 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Non-motile Cilium
Molecular Function
Protein Binding
Enzyme Binding
MRNA 3'-UTR AU-rich Region Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
MRNA Splicing, Via Spliceosome
Termination Of RNA Polymerase II Transcription
MRNA Polyadenylation
TRNA Splicing, Via Endonucleolytic Cleavage And Ligation
MRNA Export From Nucleus
MRNA 3'-end Processing
Pre-mRNA Cleavage Required For Polyadenylation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Central Nervous System Development
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development
Cell Differentiation Involved In Kidney Development
Hematopoietic Stem Cell Homeostasis
Positive Regulation Of Protein Localization To Nucleus
Pathways
Transport of Mature mRNA Derived from an Intronless Transcript
tRNA processing in the nucleus
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
Drugs
Diseases
Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS
Educational attainment (
25201988
)
Erectile dysfunction (
30583798
)
Heel bone mineral density (
30598549
)
Lung function (FEV1/FVC) (
26635082
)
Prostate-specific antigen levels (
28139693
)
Interacting Genes
57 interacting genes:
CSTF2T
GLIS2
HMOX1
IL7R
INCA1
MCM2
MIR1-2
MIR106B
MIR107
MIR122
MIR128-2
MIR138-1
MIR138-2
MIR143
MIR155
MIR15A
MIR15B
MIR16-2
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200C
MIR205
MIR206
MIR20B
MIR21
MIR214
MIR221
MIR29A
MIR31
MIR34A
MIR34B
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7E
MIRLET7F2
MIRLET7G
MIRLET7I
NEDD4
PAPOLA
POLR2A
PRRC2A
REL
TAF11
TAF12
TAF13
TAF5
TAF7
92 interacting genes:
ACTN3
AKAP9
AKT1
ANKRD36B
ARAF
ARID5A
ARNT
BCAR1
BECN1
C19orf54
CBLC
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CPSF1
CREM
CRX
CSNK2B
CTBP2
CTNNB1
EPHA2
ERBB2
FAM168B
FGFR4
FOSB
FZR1
GLIS1
GMNN
GOLGA6L9
GPSM1
GPSM2
HGF
HIF1A
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-1
KRTAP6-2
KRTAP8-1
LATS2
MAP2K3
MAP2K5
MAP2K6
MAP3K5
MDM2
MDM4
MET
MYC
NF2
NFIC
NME7
NSD3
OIP5
PIK3CA
PLEKHB1
PLEKHB2
POU6F2
PRKAR1B
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RAF1
RASSF1
RBFOX2
RBM11
RBPMS
SHOX
SOX3
SPECC1L
STK11
TEAD2
TENT5A
TERT
TLE5
TRIM32
TSC1
TWIST2
U2AF2
VAC14
VBP1
VENTX
WNK1
WT1
WWOX
XAB2
ZRANB1
Entrez ID
29894
84662
HPRD ID
05823
12256
Ensembl ID
ENSG00000071894
ENSG00000126603
Uniprot IDs
Q10570
B3KTH4
Q9BZE0
PDB IDs
6BLY
6BM0
6DNH
6F9N
6FBS
6FUW
6URG
6URO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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