CLEC2D and PLP1

Data Source:
BioGRID (two hybrid)

		CLEC2D	PLP1
Description		C-type lectin domain family 2 member D	proteolipid protein 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Integrin Alphav-beta3 Complex Myelin Sheath Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Carbohydrate Binding Natural Killer Cell Lectin-like Receptor Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Positive Regulation Of Cell Migration Neuron Projection Development Long-chain Fatty Acid Biosynthetic Process Axon Development AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Autoimmune thyroid disease ( 32581359) HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Multiple sclerosis ( 31604244)
Interacting Genes		33 interacting genes: - ADIPOQ ATP6V0C B3GALT5 BRICD5 CD68 CLDN19 CLDN2 CLEC2A CLRN2 CXCL9 DEFB121 ENTPD8 ERMP1 FAM3C FNDC9 GPR42 IL1RL1 KLRB1 KLRC1 LEPROTL1 NKG7 PLLP PLN PLP1 RPRM SEC22A SHMT2 SYT15 TM4SF18 TMEM190 TMEM80 TSPAN4	86 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYBC1 DCT DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FNDC9 GAST GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		29121	5354
HPRD ID		16134	02321
Ensembl ID		ENSG00000069493	ENSG00000123560
Uniprot IDs		Q9UHP7 W8JXM2	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs		4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT	2XPG
Enriched GO Terms of Interacting Partners?
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